幽门螺杆菌对麦卢卡蜂蜜抗菌活性的敏感性。
Susceptibility of Helicobacter pylori to the antibacterial activity of manuka honey.
作者信息
al Somal N, Coley K E, Molan P C, Hancock B M
机构信息
Department of Biological Sciences, University of Waikato, Hamilton, New Zealand.
出版信息
J R Soc Med. 1994 Jan;87(1):9-12. doi: 10.1177/014107689408700106.
Honey is a traditional remedy for dyspepsia, and is still used for this by some medical practitioners although there is no rational basis for its use. The finding that Helicobacter pylori is probably the causative agent in many cases of dyspepsia has raised the possibility that the therapeutic action of honey may be due to its antibacterial properties. Consequently, the sensitivity of Helicobacter pylori to honey was tested, using isolates from biopsies of gastric ulcers. It was found that all five isolates tested were sensitive to a 20% (v/v) solution of manuka honey in an agar well diffusion assay, but none showed sensitivity to a 40% solution of a honey in which the antibacterial activity was due primarily to its content of hydrogen peroxide. Assessment of the minimum inhibitory concentration by inclusion of manuka honey in the agar showed that all seven isolates tested had visible growth over the incubation period of 72 h prevented completely by the presence of 5% (v/v) honey.
蜂蜜是治疗消化不良的传统药物，尽管其使用缺乏合理依据，但仍有一些医学从业者将其用于此症。幽门螺杆菌可能是许多消化不良病例的致病因素，这一发现增加了蜂蜜的治疗作用可能归因于其抗菌特性的可能性。因此，利用胃溃疡活检分离出的菌株，对幽门螺杆菌对蜂蜜的敏感性进行了测试。结果发现，在琼脂孔扩散试验中，所有测试的5株分离菌株对20%（v/v）的麦卢卡蜂蜜溶液敏感，但对40%的蜂蜜溶液均不敏感，该蜂蜜的抗菌活性主要归因于其过氧化氢含量。通过在琼脂中加入麦卢卡蜂蜜来评估最低抑菌浓度，结果显示，在72小时的培养期内，所有测试的7株分离菌株在含有5%（v/v）蜂蜜的情况下完全没有可见生长。
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