鉴定针对牛白细胞共同抗原（CD45）以及一种新的广泛表达的白细胞分化抗原BoWC11的单克隆抗体。
Identification of monoclonal antibodies specific for bovine leukocyte common antigen (CD45) together with a novel broadly expressed leukocyte differentiation antigen, BoWC11.
作者信息
Bembridge G P, Howard C J, Parsons K R, Sopp P
机构信息
AFRC Institute for Animal Health, Compton, Newbury, UK.
出版信息
Vet Immunol Immunopathol. 1993 Nov;39(1-3):115-20. doi: 10.1016/0165-2427(93)90171-y.
Ten mAbs that comprised temporary clusters TC5 and TC7, plus an additional mAb, CC171, were compared. All mAbs reacted broadly and stained antigen expressed on thymocytes as well as T and B cells in peripheral blood. The five mAbs CC1, CC171, 2E8, TD14 and TD15 precipitated molecules of 180, 205 and 220 kDa, and we conclude that they recognize the bovine leukocyte common antigen and are BoCD45 mAb. The three mAbs IL-A117, 1C10 and BAGB27A precipitated molecules of 86 and 63 kDa that were broadly expressed. It is proposed that these three mAbs should be regarded as a cluster (named BoWC11 within the Second Workshop) that is distinct from BoCD45.
对构成临时簇TC5和TC7的10种单克隆抗体以及另外一种单克隆抗体CC171进行了比较。所有单克隆抗体反应广泛，可对胸腺细胞以及外周血中的T细胞和B细胞上表达的抗原进行染色。CC1、CC171、2E8、TD14和TD15这5种单克隆抗体沉淀出了180、205和220 kDa的分子，我们得出结论，它们识别牛白细胞共同抗原，是牛CD45单克隆抗体。IL-A117、1C10和BAGB27A这3种单克隆抗体沉淀出了广泛表达的86和63 kDa的分子。有人提出，这3种单克隆抗体应被视为一个与牛CD45不同的簇（在第二次研讨会上命名为BoWC11）。
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