干扰素α-2b治疗混合性冷球蛋白血症：一项对照交叉试验。
Interferon alfa-2b in mixed cryoglobulinaemia: a controlled crossover trial.
作者信息
Ferri C, Marzo E, Longombardo G, La Civita L, Lombardini F, Giuggioli D, Vanacore R, Liberati A M, Mazzoni A, Greco F
机构信息
Istituto Patologia Medica I, University of Pisa, Italy.
出版信息
Gut. 1993;34(2 Suppl):S144-5. doi: 10.1136/gut.34.2_suppl.s144.
To confirm the positive results of a preliminary trial, 26 patients with mixed cryoglobulinaemia were enrolled in a controlled, randomised, crossover trial with interferon alfa-2b. A significant improvement was seen in the purpura score and alanine aminotransferase activities during six months' treatment, and was associated with a significant decrease in cryocrit and a returning to normal of the lymphocyte CD4/CD8 ratio (in eight of nine patients). No significant variations were seen during the six month period without interferon. Only six patients withdrew from treatment, three because of side effects and three because of poor compliance.
为了证实初步试验的阳性结果，26例混合性冷球蛋白血症患者被纳入一项使用干扰素α-2b的对照、随机、交叉试验。在六个月的治疗期间，紫癜评分和丙氨酸转氨酶活性有显著改善，同时伴有冷沉淀比容显著降低以及淋巴细胞CD4/CD8比值恢复正常（9例患者中的8例）。在未使用干扰素的六个月期间未观察到显著变化。只有6例患者退出治疗，3例是因为副作用，3例是因为依从性差。
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