Klingspor L, Stitzing G, Johansen K, Murtaza A, Holmberg K
Department of Paediatrics, Danderyd's Hospital, Stockholm, Sweden.
Mycoses. 1993 Jan-Feb;36(1-2):19-24. doi: 10.1111/j.1439-0507.1993.tb00682.x.
The association of infantile diarrhoea with the occurrence of Candida species and their different morphological cell forms (pseudohyphae and/or blastospores) in faeces was studied in children of 0-15 months in a developing community (Lahore, Pakistan) where malnutrition is prevalent. Stool samples from 119 patients admitted to the Diarrhoea Treatment Unit, Department of Pediatrics, King Edward Medical College, and 46 healthy children were investigated for yeasts, bacteria, viruses and parasites. Salmonella and enteropathogenic Escherichia coli were seen in 13 (11%) each of the cases while Candida was the most frequent micro-organism, grown in cultures from 38 (32%) of the diarrhoea cases. C. tropicalis dominated (19%) over C. albicans (6%) and C. parapsilosis (3%). However, in a great number of cases (23, equals 19%), Candida did not grow in cultures but blastospores and/or pseudohyphae were seen on microscopical examination. Other Candida species and yeasts were relatively more common in the control group. Candida albicans, C. tropicalis and C. parapsilosis were the only identified agents in 23 of the cases (19%). The characteristic clinical findings in children with Candida as the only identified pathogen were malnutrition (69%), age less than 8 months (90%), and microscopically identified pseudohyphae in faecal smears (71%).
在营养不良普遍存在的发展中社区（巴基斯坦拉合尔），对0至15个月大儿童粪便中念珠菌属及其不同形态细胞形式（假菌丝和/或芽生孢子）与婴儿腹泻的相关性进行了研究。对爱德华国王医学院儿科学系腹泻治疗病房收治的119例患者以及46名健康儿童的粪便样本进行了酵母、细菌、病毒和寄生虫检测。13例（11%）腹泻病例的粪便样本中检测到沙门氏菌和肠致病性大肠杆菌，而念珠菌是最常见的微生物，38例（32%）腹泻病例的培养物中培养出念珠菌。热带念珠菌（19%）比白色念珠菌（6%）和近平滑念珠菌（3%）更为常见。然而，在大量病例（23例，占19%）中，念珠菌在培养物中未生长，但在显微镜检查中可见芽生孢子和/或假菌丝。对照组中其他念珠菌属和酵母相对更为常见。白色念珠菌、热带念珠菌和平平滑念珠菌是23例（19%）病例中仅有的鉴定病原体。以念珠菌作为唯一鉴定病原体的儿童的特征性临床发现为营养不良（69%）、年龄小于8个月（90%）以及粪便涂片显微镜检查发现假菌丝（71%）。
