对用于减轻球后注射疼痛的利多卡因-丙胺卡因乳膏（EMLA）进行双盲评估。
A double-masked evaluation of lignocaine-prilocaine cream (EMLA) used to alleviate the pain of retrobulbar injection.
作者信息
Sunderraj P, Kirby J, Joyce P W, Watson A
机构信息
Department of Ophthalmology, District General Hospital, Southport.
出版信息
Br J Ophthalmol. 1991 Mar;75(3):130-2. doi: 10.1136/bjo.75.3.130.
Abstract
A randomised, placebo controlled, double-masked study was undertaken in 115 patients undergoing cataract surgery to assess the efficacy of the anaesthetic cream EMLA (eutetic mixture of local anaesthetic, lignocaine-prilocaine) in alleviating the pain of retrobulbar injection. Sixty three patients received the EMLA cream and 52 the placebo cream. The pain was assessed objectively by the anaesthetist, who observed the reaction of the patient on needle insertion, and subjectively by the patient. Significantly lower pain scores were recorded in patients treated with EMLA cream (anaesthetist's observation: p less than 0.01, patient's assessment: p less than 0.006). No patients experienced serious side effects in either treatment group.
摘要
对115例接受白内障手术的患者进行了一项随机、安慰剂对照、双盲研究，以评估麻醉乳膏EMLA（局部麻醉剂利多卡因-丙胺卡因的 eutetic 混合物）减轻球后注射疼痛的疗效。63例患者接受EMLA乳膏，52例接受安慰剂乳膏。麻醉师通过观察患者在针头插入时的反应对疼痛进行客观评估，患者进行主观评估。使用EMLA乳膏治疗的患者疼痛评分显著更低（麻醉师观察：p<0.01，患者评估：p<0.006）。两个治疗组均无患者出现严重副作用。
相似文献
1
A double-masked evaluation of lignocaine-prilocaine cream (EMLA) used to alleviate the pain of retrobulbar injection.对用于减轻球后注射疼痛的利多卡因-丙胺卡因乳膏（EMLA）进行双盲评估。
Br J Ophthalmol. 1991 Mar;75(3):130-2. doi: 10.1136/bjo.75.3.130.
2
A comparison of amethocaine cream with lignocaine-prilocaine cream (EMLA) for reducing pain during retrobulbar injection.丁卡因乳膏与利多卡因-丙胺卡因乳膏（EMLA）用于减轻球后注射疼痛的比较。
Eye (Lond). 1994;8 ( Pt 4):465-6. doi: 10.1038/eye.1994.110.
3
EMLA does not permit pain-free retrobulbar injection.复方利多卡因乳膏不能实现无痛球后注射。
Acta Anaesthesiol Scand. 2003 Jul;47(6):739-41. doi: 10.1034/j.1399-6576.2003.00125.x.
4
EMLA prevents pain during local anesthesia for cataract surgery.EMLA可预防白内障手术局部麻醉时的疼痛。
Acta Anaesthesiol Belg. 1995;46(2):75-8.
5
Double-blind comparison of topical lignocaine-prilocaine cream (EMLA) and lignocaine infiltration for arterial cannulation in adults.成人动脉置管时外用利多卡因-丙胺卡因乳膏（EMLA）与利多卡因浸润的双盲比较。
Br J Anaesth. 1990 Aug;65(2):240-2. doi: 10.1093/bja/65.2.240.
6
The effects of EMLA and a topical formulation of 4% amethocaine (Ametop) on pain associated with retrobulbar injection.复方利多卡因乳膏和4%丁卡因局部制剂（Ametop）对球后注射相关疼痛的影响。
Anaesthesia. 1999 Jun;54(6):596-8. doi: 10.1046/j.1365-2044.1999.00842.x.
7
Reduction of pain at venous cannulation in children with a eutectic mixture of lidocaine and prilocaine (EMLA cream): comparison with placebo cream and no local premedication.利多卡因和丙胺卡因共熔混合物（EMLA乳膏）减轻儿童静脉置管时的疼痛：与安慰剂乳膏及未进行局部预处理的比较
Acta Anaesthesiol Scand. 1987 Nov;31(8):735-9. doi: 10.1111/j.1399-6576.1987.tb02655.x.
8
Double-blind evaluation of a lignocaine-prilocaine cream (EMLA) in children. Effect on the pain associated with venous cannulation.利多卡因-丙胺卡因乳膏（EMLA）用于儿童的双盲评估。对静脉穿刺相关疼痛的影响。
Br J Anaesth. 1986 Nov;58(11):1242-5. doi: 10.1093/bja/58.11.1242.
9
Efficacy of the topical anesthetic cream, EMLA, in alleviating both needle insertion and injection pain.
Ann Plast Surg. 1995 Dec;35(6):576-9. doi: 10.1097/00000637-199512000-00003.
10
Topical anesthesia with eutetic mixture of local anesthetics cream in vasectomy: 2 randomized trials.输精管结扎术中使用复方利多卡因乳膏进行表面麻醉：2项随机试验。
J Urol. 1992 Jan;147(1):98-9. doi: 10.1016/s0022-5347(17)37144-6.
引用本文的文献
1
[Application of EMLA creme before upper lid blepharoplasty].[在上睑成形术前使用EMLA乳膏]
Ophthalmologe. 2005 Aug;102(8):794-7. doi: 10.1007/s00347-005-1193-7.
2
Is lidocaine-prilocaine cream (EMLA) always useful for venous puncture in preoperative autologous blood donation?
Can J Anaesth. 1996 Mar;43(3):232-7. doi: 10.1007/BF03011740.
3
Percutaneous anaesthesia with a lignocaine-prilocaine cream (Emla) for eyelid skin surgery.用于眼睑皮肤手术的利多卡因-丙胺卡因乳膏（复方利多卡因乳膏）经皮麻醉
Br J Ophthalmol. 1994 Mar;78(3):209-10. doi: 10.1136/bjo.78.3.209.
4
Eutectic lidocaine/prilocaine cream. A review of the topical anaesthetic/analgesic efficacy of a eutectic mixture of local anaesthetics (EMLA).复方利多卡因乳膏。局部麻醉药共熔混合物（EMLA）局部麻醉/镇痛效果综述。
Drugs. 1993 Jul;46(1):126-51. doi: 10.2165/00003495-199346010-00008.
本文引用的文献
1
Does lidocaine-prilocaine cream permit painfree insertion of IV catheters in children?利多卡因-丙胺卡因乳膏能否使儿童在静脉置管时无痛？
Anesthesiology. 1982 Oct;57(4):340-2. doi: 10.1097/00000542-198210000-00024.
2
Day-case cataract surgery.日间白内障手术。
Br J Ophthalmol. 1983 May;67(5):278-81. doi: 10.1136/bjo.67.5.278.
3
Topical anaesthesia with EMLA, a new lidocaine-prilocaine cream and the Cusum technique for detection of minimal application time.使用EMLA（一种新型利多卡因-丙胺卡因乳膏）进行局部麻醉以及采用累积和(sum)技术检测最短应用时间。
Acta Anaesthesiol Scand. 1983 Dec;27(6):510-2. doi: 10.1111/j.1399-6576.1983.tb01997.x.
4
A lidocaine-prilocaine cream for superficial skin surgery and painful lesions.一种用于浅表皮肤手术和疼痛性病变的利多卡因-丙胺卡因乳膏。
Acta Derm Venereol. 1980;60(6):544-6. doi: 10.2340/0001555560544546.
5
Clinical study of a lignocaine-prilocaine cream to relieve the pain of venepuncture.用于缓解静脉穿刺疼痛的利多卡因-丙胺卡因乳膏的临床研究。
Br J Anaesth. 1985 Mar;57(3):326-8. doi: 10.1093/bja/57.3.326.
6
Double-blind evaluation of a lignocaine-prilocaine cream (EMLA) in children. Effect on the pain associated with venous cannulation.利多卡因-丙胺卡因乳膏（EMLA）用于儿童的双盲评估。对静脉穿刺相关疼痛的影响。
Br J Anaesth. 1986 Nov;58(11):1242-5. doi: 10.1093/bja/58.11.1242.
7
Outpatient cataract surgery 1982-1986.1982 - 1986年门诊白内障手术
Eye (Lond). 1987;1 ( Pt 6):728-34. doi: 10.1038/eye.1987.116.
8
9
Day-case cataract surgery.日间白内障手术。
Br J Ophthalmol. 1988 Dec;72(12):897-9. doi: 10.1136/bjo.72.12.897.
10
Evaluating the efficacy of EMLA in alleviating pain associated with lumbar puncture; comparison of open and double-blinded protocols in children.评估复方利多卡因乳膏缓解腰椎穿刺相关疼痛的疗效；儿童开放与双盲方案的比较。
Pain. 1990 Jul;42(1):31-34. doi: 10.1016/0304-3959(90)91088-Z.
Zotero 插件