Irsfeld S, Klement W, Lipfert P
Department of Clinical Anaesthesiology, Heinrich-Heine-University Düsseldorf, Germany.
Br J Anaesth. 1993 Sep;71(3):375-8. doi: 10.1093/bja/71.3.375.
We have compared the efficacy of two non-invasive methods of transdermal anaesthesia: application of EMLA cream and iontophoresis of 5% lignocaine with adrenaline 1:50,000 in six healthy subjects. We tested depth of tissue penetration (pinprick) and effect on pain evoked by i.v. injection. After iontophoresis, pain on i.v. injection was abolished in five of six volunteers, whereas EMLA had no effect. We conclude that local anaesthetics penetrate deeply enough to numb both veins and skin with iontophoresis only.
对六名健康受试者应用EMLA乳膏和离子导入5%利多卡因加1:50,000肾上腺素。我们测试了组织渗透深度（针刺）以及对静脉注射诱发疼痛的影响。离子导入后，六名志愿者中有五名静脉注射时的疼痛消失，而EMLA则没有效果。我们得出结论，局部麻醉药仅通过离子导入就能深入渗透，使静脉和皮肤都麻木。
