特发性系统性红斑狼疮患者的乙酰化表型与环境化学物质暴露
Acetylation phenotypes and environmental chemical exposure of people with idiopathic systemic lupus erythematosus.
作者信息
Reidenberg M M, Drayer D E, Lorenzo B, Strom B L, West S L, Snyder E S, Freundlich B, Stolley P D
机构信息
Department of Pharmacology, Cornell University Medical College, New York, NY 10021.
出版信息
Arthritis Rheum. 1993 Jul;36(7):971-3. doi: 10.1002/art.1780360714.
OBJECTIVE
To test the hypotheses that there is an excess percentage of slow acetylators among patients with idiopathic systemic lupus erythematosus (SLE) and that these patients had excessive exposure to environmental amines and hydrazines before the onset of illness.
METHODS
Case-control study with structured interview and acetylation phenotyping.
RESULTS
No excess proportion of slow acetylators or environmental amine exposure was found.
CONCLUSION
Slow acetylation phenotype and exposure to environmental amines are not principal causes of idiopathic SLE.
目的
检验以下假设，即特发性系统性红斑狼疮（SLE）患者中慢乙酰化者的比例过高，且这些患者在发病前过度暴露于环境胺和肼。
方法
采用结构化访谈和乙酰化表型分析的病例对照研究。
结果
未发现慢乙酰化者比例过高或存在环境胺暴露情况。
结论
慢乙酰化表型和环境胺暴露不是特发性SLE的主要病因。
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