Nieman R B, Fleming J, Coker R J, Harris J R, Mitchell D M
Department of Respiratory Medicine, St Mary's Hospital, London, UK.
AIDS. 1993 May;7(5):705-10. doi: 10.1097/00002030-199305000-00015.
To determine whether HIV-1-seropositive cigarette smokers progress more rapidly to AIDS than HIV-1-seropositive non-smokers.
The genitourinary medicine outpatient department of St Mary's Hospital, London, which is a London University teaching hospital (tertiary care centre).
Case series of 84 individuals with AIDS who provided accurate details of their smoking habits before their AIDS-defining diagnosis.
Progression time to AIDS in relation to smoking habit.
Progression time to AIDS (all diagnoses) was significantly reduced in HIV-1-seropositive smokers: median time to AIDS was 8.17 months for smokers (n = 43) and 14.50 months for non-smokers (n = 41) (P = 0.003). Smokers developed Pneumocystis carinii pneumonia (PCP) more rapidly than non-smokers, with a median time to PCP of 9.0 months, compared with 16.0 months for non-smokers (P = 0.002). Smoking had no significant effect on progression time to AIDS when not due to PCP.
Cigarette smoking by HIV-1-seropositive individuals is associated with a more rapid development of AIDS and should be discouraged.
确定HIV-1血清反应阳性的吸烟者比HIV-1血清反应阳性的非吸烟者进展为艾滋病的速度是否更快。
伦敦大学教学医院（三级护理中心）圣玛丽医院的泌尿生殖医学门诊部。
对84例艾滋病患者进行病例系列研究，这些患者在确诊艾滋病之前提供了准确的吸烟习惯细节。
与吸烟习惯相关的艾滋病进展时间。
HIV-1血清反应阳性的吸烟者进展为艾滋病（所有诊断）的时间显著缩短：吸烟者（n = 43）进展为艾滋病的中位时间为8.17个月，非吸烟者（n = 41）为14.50个月（P = 0.003）。吸烟者患卡氏肺孢子虫肺炎（PCP）的速度比非吸烟者更快，患PCP的中位时间为9.0个月，而非吸烟者为16.0个月（P = 0.002）。当不是由PCP导致时，吸烟对进展为艾滋病的时间没有显著影响。
HIV-1血清反应阳性的个体吸烟与艾滋病的更快发展相关，应予以劝阻。
