Alanen A M, Parkkola R K, Lillsunde I G, Virtanen K O, Kalimo H O, Komu M E, Kormano M J
Departments of Diagnostic Radiology and Pathology, Turku University Central Hospital, Finland.
Invest Radiol. 1993 Jun;28(6):529-32. doi: 10.1097/00004424-199306000-00013.
The variation of measured magnetic resonance T1 relaxation times of autopsied human muscle samples is confusing. Hence, the authors studied rats' muscles to evaluate the effect of fiber type, the relative area of nonmyofiber space, fat and water content, cell death, and the mechanism of death on proton T1.
Rats were studied on a 0.1 T magnetic resonance device. We studied how death by cervical dislocation, pentobarbital injection, or a combination of these methods, as well as the amount of time lapsed after death, variably affected T1.
Death itself did not affect T1, but the mechanism of death did: rats killed by cervical dislocation after ether anesthesia had longer T1 than those killed with an overdose of pentobarbital. T1 was significantly shorter 1 day after death than at 4 hours after and returned to baseline levels within 4 days after death. Repeated warming caused variation in T1 and obscured other possible changes.
Investigation methods should be strictly controlled and standardized before measurements of the relaxation time, T1, of muscle tissue will provide consistent results.
经尸检的人体肌肉样本的磁共振T1弛豫时间测量值存在差异，令人困惑。因此，作者研究了大鼠肌肉，以评估纤维类型、非肌纤维空间的相对面积、脂肪和水分含量、细胞死亡以及死亡机制对质子T1的影响。
在0.1T磁共振设备上对大鼠进行研究。我们研究了通过颈椎脱臼、戊巴比妥注射或这些方法的组合导致的死亡，以及死亡后经过的时间如何不同程度地影响T1。
死亡本身并不影响T1，但死亡机制会影响：乙醚麻醉后通过颈椎脱臼处死的大鼠T1比过量戊巴比妥处死的大鼠更长。死亡1天后T1明显短于死亡4小时后，且在死亡后4天内恢复到基线水平。反复升温导致T1变化并掩盖了其他可能的变化。
在肌肉组织弛豫时间T1的测量能够提供一致结果之前，调查方法应严格控制并标准化。
