Sanmartí R, Pañella D, Brancós M A, Canela J, Collado A, Brugués J
Hospital General de Vic, Osona, Barcelona, Spain.
Ann Rheum Dis. 1993 Jun;52(6):418-22. doi: 10.1136/ard.52.6.418.
To undertake an epidemiological survey of the prevalence of radiological chondrocalcinosis in the elderly population of Osona, a rural area of Catalonia, north east Spain.
Knee and wrist radiographs were performed on 261 subjects (141 women, 120 men) aged at least 60 years, who attended a series of 35 general practitioners for various medical problems.
Twenty seven subjects had articular chondrocalcinosis, which represents a crude prevalence of 10%. Articular chondrocalcinosis was more often observed in women than in men (14 v 6%). Articular chondrocalcinosis increases in occurrence with age, rising from 7% in subjects aged 60-69 years to 43% in subjects older than 80 years. A similar occurrence of articular chondrocalcinosis was noted in the indigenous population, in which several cases of familial chondrocalcinosis have previously been reported, and in subjects born in other areas of Spain. All but one subject with articular chondrocalcinosis had chondrocalcinosis of the knee. The occurrence of rheumatic disorders did not differ significantly between subjects with articular chondrocalcinosis and those without.
Articular chondrocalcinosis is an age related disorder, which could partly explain the discrepancies in its prevalence reported in previous studies. In most subjects with articular chondrocalcinosis recruited from an unselected population the clinical manifestations are probably mild or even absent.
对西班牙东北部加泰罗尼亚农村地区奥索纳老年人群放射性软骨钙质沉着症的患病率进行流行病学调查。
对261名年龄至少60岁的受试者(141名女性,120名男性)进行了膝部和腕部X光检查,这些受试者因各种医疗问题就诊于35名全科医生。
27名受试者患有关节软骨钙质沉着症,粗患病率为10%。关节软骨钙质沉着症在女性中比在男性中更常见(14%对6%)。关节软骨钙质沉着症的发生率随年龄增长而增加,从60 - 69岁受试者中的7%上升至80岁以上受试者中的43%。在当地人群中观察到类似的关节软骨钙质沉着症发生率,此前曾报道过几例家族性软骨钙质沉着症病例,在出生于西班牙其他地区的受试者中也是如此。除一名受试者外,所有患有关节软骨钙质沉着症的受试者均有膝关节软骨钙质沉着症。患有和未患有关节软骨钙质沉着症的受试者之间风湿性疾病的发生率没有显著差异。
关节软骨钙质沉着症是一种与年龄相关的疾病,这可能部分解释了先前研究中报道的患病率差异。在从未经过筛选的人群中招募的大多数患有关节软骨钙质沉着症的受试者中,临床表现可能很轻微甚至没有。