Nachbar F, Korting H C, Vogl T
Department of Dermatology, University of Munich, FRG.
Dermatology. 1993;187(1):42-6. doi: 10.1159/000247196.
A 46-year-old woman presented with an unusual erythema multiforme-like eruption and severe headache 10 days after treatment with pyritinol for cerebral concussion. Histopathologic findings were consistent with erythema multiforme. Skin lesions and headache cleared after withdrawal of the drug. According to neurological examination and magnetic resonance imaging of the brain, the headache may have resulted from a slight, pyritinol-induced vasculitis. Previous reports on severe pyritinol-induced side effects and possible pathogenetic mechanisms are reviewed. Since pyritinol cannot be considered as an essential drug for cerebral concussion, adverse effects as described here raise doubts as to its general use in the given indication.
一名46岁女性在接受脑复新（吡硫醇）治疗脑震荡10天后，出现了不寻常的多形红斑样皮疹和严重头痛。组织病理学检查结果与多形红斑一致。停药后皮肤病变和头痛症状消失。根据神经系统检查和脑部磁共振成像，头痛可能是由轻微的、脑复新诱发的血管炎引起的。本文回顾了先前关于脑复新严重副作用及可能发病机制的报道。由于脑复新不能被视为治疗脑震荡的必需药物，此处所述的不良反应引发了对其在该适应症中普遍应用的质疑。
