[人类嗜T淋巴细胞病毒I型（HTLV-I）携带者的葡萄膜炎——3. 分子生物学研究]

[Uveitis in human T-lymphotropic virus type I (HTLV-I) carriers--3. A molecular biological study].

作者信息

Nakashima S, Shirao M, Mochizuki M, Watanabe T, Mori S, Araki S, Miyata N, Yamaguchi K, Takatsuki K

机构信息

Department of Ophthalmology, Kurume University School of Medicine, Japan.

出版信息

Nippon Ganka Gakkai Zasshi. 1993 Jun;97(6):741-6.

PMID:8328343

Abstract

The presence of proviral DNA of human T-lymphotropic virus type I (HTLV-I) in the inflammatory cells in the aqueous humor was examined by polymerase chain reaction. The proviral DNA was detected in all the tested patients (n = 9) with HTLV-I uveitis. On the other hand, the provirus was not detected in 2 out of 3 HTLV-I seropositive patients with other types of uveitis, i.e., Behçet's disease, toxoplasmosis and Vogt-Koyanagi-Harada's disease. None of the 11 seronegative patients with other types of uveitis or senile cataract had proviral DNA in the aqueous humor. Thus, the fact that HTLV-I-infected cells were present in the aqueous humor of all HTLV-I uveitis patients suggests significant involvement of HTLV-I in the pathophysiology of the uveitis.

摘要

通过聚合酶链反应检测了房水中炎症细胞中人嗜T淋巴细胞病毒I型（HTLV-I）前病毒DNA的存在情况。在所有检测的9例HTLV-I葡萄膜炎患者中均检测到前病毒DNA。另一方面，在3例HTLV-I血清学阳性的其他类型葡萄膜炎患者（即白塞病、弓形虫病和Vogt-小柳原田病）中，有2例未检测到前病毒。11例其他类型葡萄膜炎或老年性白内障的血清学阴性患者中，房水中均无前病毒DNA。因此，所有HTLV-I葡萄膜炎患者房水中均存在HTLV-I感染细胞这一事实表明，HTLV-I在葡萄膜炎的病理生理学中起重要作用。