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The regulation of the immune response of mice to Haemophilus influenzae type b capsular polysaccharide.小鼠对b型流感嗜血杆菌荚膜多糖免疫反应的调节
Immunology. 1978 Jan;34(1):149-56.
2
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引用本文的文献

1
Maternal-foetal interaction, antibody formation, and metabolic response in mice immunized with pneumococcal polysacharides.肺炎球菌多糖免疫小鼠的母胎相互作用、抗体形成及代谢反应
Immunology. 1980 Sep;41(1):45-54.
2
Immunoglobulin M and G antibody responses and persistence of these antibodies in adults after vaccination with a combined meningococcal group A and group C polysaccharide vaccine.成人接种A群和C群脑膜炎球菌结合多糖疫苗后免疫球蛋白M和G抗体反应及这些抗体的持久性。
Infect Immun. 1982 Aug;37(2):579-85. doi: 10.1128/iai.37.2.579-585.1982.
3
Characterization of the murine immune response to type 6 pneumococcal polysaccharide.小鼠对6型肺炎球菌多糖免疫反应的特征
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4
Evolution of the subclass of IgG antibody to type 3 pneumococcal polysaccharide during childhood.儿童期针对3型肺炎球菌多糖的IgG抗体亚类的演变。
Clin Exp Immunol. 1987 Nov;70(2):449-55.
5
T-cell modulation of the murine antibody response to Neisseria meningitidis group A capsular polysaccharide.T细胞对小鼠针对A群脑膜炎奈瑟菌荚膜多糖的抗体反应的调节作用。
Infect Immun. 1988 Jan;56(1):259-66. doi: 10.1128/iai.56.1.259-266.1988.
6
Evidence that L-rhamnose is the antigenic determinant of hyporesponsiveness of BALB/c mice to Klebsiella pneumoniae type 47.有证据表明L-鼠李糖是BALB/c小鼠对47型肺炎克雷伯菌低反应性的抗原决定簇。
Infect Immun. 1978 Oct;22(1):18-21. doi: 10.1128/iai.22.1.18-21.1978.

本文引用的文献

1
Immunity to disease caused by Hemophilus influenzae type b. II. Specificity and some biologic characteristics of "natural," infection-acquired, and immunization-induced antibodies to the capsular polysaccharide of Hemophilus influenzae type b.b型流感嗜血杆菌引起疾病的免疫性。二、针对b型流感嗜血杆菌荚膜多糖的“天然”、感染获得性及免疫诱导性抗体的特异性及某些生物学特性。
J Immunol. 1971 Oct;107(4):1081-9.
2
Immunity to Hemophilus influenzae type b. I. The isolation, and some physicochemical, serologic and biologic properties of the capsular polysaccharide of Hemophilus influenzae type b.b型流感嗜血杆菌的免疫性。I. b型流感嗜血杆菌荚膜多糖的分离及其一些物理化学、血清学和生物学特性
J Immunol. 1971 Oct;107(4):1071-80.
3
Immunological studies of nude mice.裸鼠的免疫学研究。
Contemp Top Immunobiol. 1974;3:243-63. doi: 10.1007/978-1-4684-3045-5_10.
4
T cell control of antibody production.T细胞对抗体产生的控制。
Contemp Top Immunobiol. 1974;3:1-40. doi: 10.1007/978-1-4684-3045-5_1.
5
Responses of children immunized with the capsular polysaccharide of Hemophilus influenzae, type b.接种b型流感嗜血杆菌荚膜多糖疫苗的儿童的反应。
Pediatrics. 1973 Nov;52(5):637-44.
6
Immunization of humans with polyribophosphate, the capsular antigen of Hemophilus influenzae, type b.用b型流感嗜血杆菌的荚膜抗原多聚核糖磷酸对人类进行免疫接种。
J Clin Invest. 1972 Jan;51(1):39-44. doi: 10.1172/JCI106794.
7
Genetic control of the antibody response to type 3 pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness.小鼠对3型肺炎球菌多糖抗体反应的遗传控制。I. 有证据表明一个X连锁基因在决定反应性方面起决定性作用。
J Exp Med. 1972 Oct 1;136(4):931-49. doi: 10.1084/jem.136.4.931.
8
Suppressor T cells.抑制性T细胞
J Immunol. 1972 Mar;108(3):586-90.
9
Use of erythrocytes sensitized with purified pneumococcal polysaccharides for the assay of antibody and antibody-producing cells.使用经纯化肺炎球菌多糖致敏的红细胞进行抗体及抗体产生细胞的检测。
Appl Microbiol. 1969 Mar;17(3):422-6. doi: 10.1128/am.17.3.422-426.1969.
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Genetic determinants of immunological responsiveness.免疫反应性的遗传决定因素。
Adv Immunol. 1974;18:1-66. doi: 10.1016/s0065-2776(08)60307-7.

小鼠对b型流感嗜血杆菌荚膜多糖免疫反应的调节

The regulation of the immune response of mice to Haemophilus influenzae type b capsular polysaccharide.

作者信息

Lee C J, Malik F G, Robbins J B

出版信息

Immunology. 1978 Jan;34(1):149-56.

PMID:75178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457327/
Abstract

The regulation of age-related antibody response to Haemophilus influenzae type b polysaccharide (HITB-PS) was studied by measuring the splenic plaque forming cells (PFC) following immunization with this capsular polysaccharide. The magnitude of PFC response to HITB-PS was found to be dose-related, enhanced by Freund's complete adjuvant and influenced by the genetic strain of mice. Priming with a low dose of HITB-PS did not induce a state of immunological unresponsiveness. Treatment with antilymphocyte serum significantly increased the PFC response to HITB-PS. Athymic nude mice showed an enhanced ability to induce both IgG and IgA-PFC responses as well as a significant increase in the biosynthesis of protein and mitogenicity in spleen cells. These findings suggest that the immune response to HITB-PS is regulated by the suppressor T cell. The magnitude of the IgM-PFC response induced by HITB-PS in mice increased gradually from two weeks of age and reached a plateau at 8 weeks. Treatment with fetuin resulted in the inhibition of direct IgM and IgG-PFC responses to HITB-PS; the suppressive effect on the immune response was more profound and lasting in young than in adult mice.

摘要

通过测量用b型流感嗜血杆菌多糖（HITB-PS）免疫后的脾脏斑块形成细胞（PFC），研究了与年龄相关的对该荚膜多糖抗体反应的调节。发现对HITB-PS的PFC反应强度与剂量相关，弗氏完全佐剂可增强该反应，且受小鼠遗传品系的影响。用低剂量HITB-PS进行初次免疫不会诱导免疫无反应状态。抗淋巴细胞血清处理显著增加了对HITB-PS的PFC反应。无胸腺裸鼠诱导IgG和IgA-PFC反应的能力增强，同时脾脏细胞中蛋白质生物合成和有丝分裂原性显著增加。这些发现表明对HITB-PS的免疫反应受抑制性T细胞调节。HITB-PS在小鼠中诱导的IgM-PFC反应强度从2周龄开始逐渐增加，在8周时达到平台期。用胎球蛋白处理导致对HITB-PS的直接IgM和IgG-PFC反应受到抑制；对免疫反应的抑制作用在幼鼠中比成年鼠更显著且持久。