分泌型免疫球蛋白A和G抗体可阻止大肠杆菌黏附于人类尿道上皮细胞。
Secretory immunoglobulin A and G antibodies prevent adhesion of Escherichia coli to human urinary tract epithelial cells.
作者信息
Svanborg-Edén C, Svennerholm A M
出版信息
Infect Immun. 1978 Dec;22(3):790-7. doi: 10.1128/iai.22.3.790-797.1978.
Abstract
The adhesion of Escherichia coli to human urinary tract epithelial cells was inhibited by commercial gamma globulin, the total immunoglobulin fraction of human breast milk and urine, as well as the isolated immunoglobulin G and secretory immunoglobulin A fractions of urine from patients with acute pyelonephritis. Urinary anti-O6 antibodies reduced the adhesion of several O6 strains. Absorption of antibodies to the lipopolysaccharide of the adhering strain markedly decreased the antiadhesive capacity of all the immunoglobulin preparations, whereas elimination of antibodies to the capsular polysaccharide antigen consistently had a small but not significant effect. When urine was absorbed with whole, live bacteria of the patients' infecting strains, the antiadhesive effect completely disappeared. Absorption with bacteria lacking pili only partially reduced this effect.
摘要
商业γ球蛋白、人母乳和尿液的总免疫球蛋白组分以及急性肾盂肾炎患者尿液中分离出的免疫球蛋白G和分泌型免疫球蛋白A组分可抑制大肠杆菌与人泌尿道上皮细胞的黏附。尿液中的抗O6抗体可降低几种O6菌株的黏附。将抗体吸附到黏附菌株的脂多糖上可显著降低所有免疫球蛋白制剂的抗黏附能力，而去除针对荚膜多糖抗原的抗体始终只有微小但不显著的影响。当尿液用患者感染菌株的完整活细菌吸收时，抗黏附作用完全消失。用缺乏菌毛的细菌吸收只能部分降低这种作用。
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