Faden H, Sutyla P, Ogra P L
Infect Immun. 1979 Jun;24(3):673-8. doi: 10.1128/iai.24.3.673-678.1979.
The effects of Newcastle disease, herpes simplex, vaccinia, encephalomyocarditis, vesicular stomatitis and reoviruses on in vitro function of neutrophils were studied in Ficoll-Hypaque-separated polymorphonuclear leukocytes (PMN) employing the technique of luminol-dependent chemiluminescence. Newcastle disease, herpes simplex vaccinia, and reoviruses depressed chemiluminescence by 98, 65, 46, and 29%, respectively, while encephalomyocarditis and vesicular stomatitis viruses had no inhibitory effect. None of the viruses affected phagocytosis or PMN viability. These observations suggest significant alteration of neutrophil function by interaction with several viruses in in vitro settings. It is suggested that similar changes in PMN function may occur during in vivo viral infection.
利用鲁米诺依赖的化学发光技术，在经聚蔗糖-泛影葡胺分离的多形核白细胞（PMN）中研究了新城疫病毒、单纯疱疹病毒、痘苗病毒、脑心肌炎病毒、水疱性口炎病毒和呼肠孤病毒对中性粒细胞体外功能的影响。新城疫病毒、单纯疱疹病毒、痘苗病毒和呼肠孤病毒分别使化学发光降低了98%、65%、46%和29%，而脑心肌炎病毒和水疱性口炎病毒没有抑制作用。这些病毒均未影响吞噬作用或PMN的活力。这些观察结果表明，在体外环境中，中性粒细胞功能通过与几种病毒相互作用而发生显著改变。提示在体内病毒感染期间，PMN功能可能发生类似变化。
