Scherer R, Kern B, Braun-Falco O
Klin Wochenschr. 1977 Feb 1;55(3):137-40. doi: 10.1007/BF01490241.
The effect of psoralen plus long wavelength ultraviolet light (UVA) on 3H-thymidine uptake of PHA stimulated human lymphocytes was investigated. PHA induced lymphocyte transformation was inhibited by the combined action of psoralen and UVA irradiation in a dose related manner. Inhibition of DNA-synthesis occurred at concentrations of psoralen that can be expected in the serum of patients treated by systemic photochemotherapy. No effect was noted at these psoralen concentrations in the absence of UVA irradiation. Also did UVA irradiation in the absence of psoralen not inhibit 3H-thymidine incorporation into PHA stimulated lymphocytes.
研究了补骨脂素加长波紫外线（UVA）对PHA刺激的人淋巴细胞摄取3H-胸腺嘧啶核苷的影响。补骨脂素和UVA照射的联合作用以剂量相关的方式抑制了PHA诱导的淋巴细胞转化。在系统性光化学疗法治疗的患者血清中预期的补骨脂素浓度下，DNA合成受到抑制。在没有UVA照射的情况下，这些补骨脂素浓度未观察到影响。在没有补骨脂素的情况下，UVA照射也不会抑制3H-胸腺嘧啶核苷掺入PHA刺激的淋巴细胞。
