Simpson K J, Chalmers N, Redhead D N, Finlayson N D, Bouchier I A, Hayes P C
Department of Medicine, Royal Infirmary, Edinburgh.
Gut. 1993 Jul;34(7):968-73. doi: 10.1136/gut.34.7.968.
The insertion of a transjugular intrahepatic portasystemic stent shunt (TIPSS) was evaluated in 22 patients with recurrent upper gastrointestinal haemorrhage related to portal hypertension (bleeding from oesophageal varices 10, gastric varices six, portal hypertensive gastropathy six). TIPSS was successfully performed electively in 15 patients and as an emergency in three patients. Twelve patients have had no further admissions with bleeding after TIPSS. Single episodes of bleeding were noted in six patients after TIPSS associated with shunt thrombosis (two), intimal hyperplasia within the shunt (two), and shunt migration (one). Another patient presented with reaccumulated ascites suggesting poor shunt function but died from massive variceal haemorrhage before further assessment could be performed. There was one death related to the procedure. Two patients developed encephalopathy after TIPSS, in one patient this was controlled by the insertion of a smaller diameter stent within the existing TIPSS. Several complications arose in earlier patients that have not recurred after modification of the initial technique. TIPSS can be life saving and is effective in controlling variceal haemorrhage and rebleeding from oesophageal or gastric varices and portal hypertensive gastropathy. Larger and longer term studies are required, however, to define the role of TIPSS in the overall management of such patients.
对22例与门静脉高压相关的复发性上消化道出血患者(食管静脉曲张出血10例、胃静脉曲张出血6例、门静脉高压性胃病出血6例)进行了经颈静脉肝内门体分流术(TIPSS)评估。15例患者择期成功实施了TIPSS,3例患者作为急诊实施。12例患者在TIPSS术后未因出血再次入院。6例患者在TIPSS术后出现单次出血,分别与分流血栓形成(2例)、分流内内膜增生(2例)和分流移位(1例)有关。另1例患者出现腹水再积聚,提示分流功能不良,但在进一步评估前死于大量静脉曲张出血。有1例死亡与手术相关。2例患者在TIPSS术后发生脑病,其中1例通过在现有TIPSS内植入较小直径的支架得到控制。早期患者出现了几种并发症,在初始技术改进后未再复发。TIPSS可挽救生命,对控制食管或胃静脉曲张及门静脉高压性胃病引起的静脉曲张出血和再出血有效。然而,需要更大规模的长期研究来确定TIPSS在此类患者整体管理中的作用。