季节性变应性鼻炎对气道黏膜吸收51铬标记依地酸的影响。
Effect of seasonal allergic rhinitis on airway mucosal absorption of chromium-51 labelled EDTA.
作者信息
Greiff L, Wollmer P, Svensson C, Andersson M, Persson C G
机构信息
Department of Otorhinolaryngology, University Hospital of Lund, Sweden.
出版信息
Thorax. 1993 Jun;48(6):648-50. doi: 10.1136/thx.48.6.648.
Abstract
BACKGROUND
Hyperpermeability of the airway mucosa is thought to be characteristic of allergic rhinitis and asthma. Nine subjects with seasonal rhinitis caused by birch pollen were studied and the nasal mucosal absorption of chromium-51 labelled EDTA was examined both in an asymptomatic period before the season and late into the season when significant allergic rhinitis symptoms were present.
METHODS
A nasal pool device was used to keep a concentration of the absorption tracer in contact with a larger part of the mucosa of the ipsilateral nasal cavity. Absorption was allowed for 15 minutes and measured as the radioactivity appearing in the 24 hour urine sample.
RESULTS
The nasal absorption of 51Cr-EDTA in subjects with seasonal allergic rhinitis was less during active disease than before the season.
CONCLUSIONS
An airway epithelial barrier that is subject to prolonged eosinophilic inflammation may not be disrupted but may rather increase its functional tightness.
摘要
背景
气道黏膜的高通透性被认为是变应性鼻炎和哮喘的特征。对9名由桦树花粉引起季节性鼻炎的受试者进行了研究，在季节前无症状期和季节后期出现明显变应性鼻炎症状时，检测了51铬标记的乙二胺四乙酸（EDTA）的鼻黏膜吸收情况。
方法
使用鼻池装置使吸收示踪剂的浓度与同侧鼻腔大部分黏膜接触。吸收15分钟，并测量24小时尿液样本中出现的放射性。
结果
季节性变应性鼻炎患者在疾病活动期的51铬-EDTA鼻吸收低于季节前。
结论
长期受嗜酸性粒细胞炎症影响的气道上皮屏障可能不会被破坏，反而可能增加其功能紧密性。
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