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一种市售缬草根提取物的中枢神经抑制活性表征

Characterisation of the central nervous depressant activity of a commercially available valerian root extract.

作者信息

Leuschner J, Müller J, Rudmann M

机构信息

LPT Laboratory of Pharmacology, Hamburg, Fed. Rep. of Germany.

出版信息

Arzneimittelforschung. 1993 Jun;43(6):638-41.

PMID:8352816
Abstract

The evaluation of a commercially available valerian root extract (Valdispert) revealed pronounced sedative properties in the mouse with respect to a reduction in motility and an increase in the thiopental sleeping-time. A direct comparison with diazepam and chlorpromazine revealed a moderate sedative activity for the tested extract. The extract showed only weak anticonvulsive properties.

摘要

对市售缬草根提取物(Valdispert)的评估显示,该提取物对小鼠具有显著的镇静特性,表现为活动能力降低以及硫喷妥钠睡眠时间延长。与地西泮和氯丙嗪的直接比较表明,受试提取物具有中等程度的镇静活性。该提取物仅显示出微弱的抗惊厥特性。

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