Gray R G, Altman R D
Arthritis Rheum. 1977 Jan-Feb;20(1):35-41. doi: 10.1002/art.1780200106.
Progressive systemic sclerosis (PSS) developed in a 6-year-old boy and in his 38-year-old mother 9 years later. Both parent and child had Raynaud's phenomenon, integumental sclerosis, and pulmonary involvement, but they differed in other aspects of their disease. Previous descriptions of the familial occurrence of PSS are reviewed and compared to the present case reports. Environmental and genetic factors of possible etiologic significance are discussed.
一名6岁男孩患上了进行性系统性硬化症（PSS），9年后，他38岁的母亲也患上了该病。母子二人都有雷诺现象、皮肤硬化和肺部受累，但在疾病的其他方面存在差异。本文回顾了先前关于PSS家族发病情况的描述，并与本病例报告进行了比较。还讨论了可能具有病因学意义的环境和遗传因素。
