McConnell C D, Adair B M, McNulty M S
Department of Agriculture, Veterinary Sciences Division, Stormont, Belfast, Northern Ireland.
Avian Dis. 1993 Apr-Jun;37(2):358-65.
One-day-old chicks were inoculated intramuscularly with chicken anemia virus (CAV). Four birds were killed at 7, 14, 21, 28, and 42 days postinoculation (PI), and macrophages were recovered from spleen and bone-marrow suspensions. These were tested for interleukin-1 (IL-1) production, Fc receptor expression, phagocytosis, and bactericidal activity. Macrophages recovered from uninoculated chickens at the same sample times, and exposed to CAV in vitro, were also tested. IL-1 production, Fc receptor expression, phagocytosis, and bactericidal activity were significantly lower in all macrophage cultures from CAV-inoculated chickens, and in cultures exposed to the virus in vitro, than in uninfected controls.
将一日龄雏鸡通过肌肉注射接种鸡贫血病毒（CAV）。在接种后第7、14、21、28和42天处死4只鸡，从脾脏和骨髓悬液中分离出巨噬细胞。检测这些巨噬细胞的白细胞介素-1（IL-1）产生、Fc受体表达、吞噬作用和杀菌活性。同时，对在相同采样时间从未接种鸡中分离出并在体外暴露于CAV的巨噬细胞也进行检测。与未感染对照组相比，接种CAV的鸡的所有巨噬细胞培养物以及体外暴露于该病毒的培养物中的IL-1产生、Fc受体表达、吞噬作用和杀菌活性均显著降低。
