Wenstrom K D, Syrop C H, Hammitt D G, Van Voorhis B J
Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City.
Fertil Steril. 1993 Sep;60(3):510-4. doi: 10.1016/s0015-0282(16)56169-x.
To determine the incidence of monochorionic twinning in pregnancies resulting from assisted reproduction technologies (ARTs).
We reviewed our experience with 218 ART pregnancies achieved over 3 years. All patients underwent transvaginal ultrasound 26 and 36 days after oocyte retrieval. The presence of two yolk sacs or two fetal poles within one sac suggested monochorionicity, and was confirmed by follow-up ultrasound and placental pathology. The various ARTs were compared to determine if any method had an increased incidence of monochorionicity compared to any other method. Statistical analysis was performed employing Chi Square analysis.
The incidence of monochorionicity in all gestations was 3.2% (8 times background rate); among multiple gestations it was 9.8%. The rates of monochorionicity for each ART appeared similar.
The incidence of monochorionic twinning is increased in pregnancies resulting from ART. Careful ultrasound evaluation of such pregnancies for monochorionicity is strongly recommended, both for planning of prenatal care and when considering a multifetal pregnancy reduction procedure.
确定辅助生殖技术（ART）导致的妊娠中单绒毛膜双胎的发生率。
我们回顾了3年期间218例ART妊娠的经验。所有患者在取卵后26天和36天接受经阴道超声检查。一个孕囊内出现两个卵黄囊或两个胎芽提示单绒毛膜性，并通过后续超声检查和胎盘病理检查得以证实。对各种ART方法进行比较，以确定是否有任何一种方法的单绒毛膜性发生率高于其他方法。采用卡方分析进行统计学分析。
所有妊娠中单绒毛膜性的发生率为3.2%（是背景发生率的8倍）；在多胎妊娠中为9.8%。每种ART方法的单绒毛膜性发生率似乎相似。
ART导致的妊娠中单绒毛膜双胎的发生率增加。强烈建议对此类妊娠进行仔细的超声检查以评估单绒毛膜性，这对于产前护理规划以及考虑多胎妊娠减胎术时均很重要。
