T细胞受体γ基因座可变区基因的有序重排与未重排基因的转录相关。
Ordered rearrangement of variable region genes of the T cell receptor gamma locus correlates with transcription of the unrearranged genes.
作者信息
Goldman J P, Spencer D M, Raulet D H
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
出版信息
J Exp Med. 1993 Mar 1;177(3):729-39. doi: 10.1084/jem.177.3.729.
Abstract
T cell receptor V gamma genes rearrange to the J gamma 1 gene segment in a highly ordered fashion during development. We demonstrate a striking correlation between the pattern of expression of unrearranged V gamma genes and the timing of their rearrangement. Thus, the increases in V gamma 2 rearrangements, and decreases in V gamma 3 and V gamma 4 rearrangements observed during development are paralleled by increasing or decreasing levels of the corresponding unrearranged V gene transcript. We also provide evidence that both the V gamma 3 and V gamma 4 genes are accessible in mature V gamma 3+ cells, but that the V gamma 4 gene may be inaccessible in the progenitors of V gamma 3 cells. The results suggest that regulated local accessibility of the chromatin surrounding V gamma genes is responsible for ordered V gamma gene rearrangement during development.
摘要
在发育过程中，T细胞受体Vγ基因以高度有序的方式重排至Jγ1基因片段。我们证明了未重排的Vγ基因表达模式与其重排时间之间存在显著相关性。因此，在发育过程中观察到的Vγ2重排增加以及Vγ3和Vγ4重排减少，与相应未重排V基因转录本水平的增加或减少相平行。我们还提供证据表明，在成熟的Vγ3+细胞中，Vγ3和Vγ4基因均可接近，但在Vγ3细胞的祖细胞中，Vγ4基因可能无法接近。结果表明，Vγ基因周围染色质的调控局部可及性是发育过程中Vγ基因有序重排的原因。
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