麻风病患者血清中的可溶性肿瘤坏死因子α受体
Soluble tumor necrosis factor alpha receptors in sera from leprosy patients.
作者信息
Munk M E, Anding P, Schettini A P, Cunha M G, Kaufmann S H
机构信息
Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.
出版信息
Infect Immun. 1999 Jan;67(1):423-5. doi: 10.1128/IAI.67.1.423-425.1999.
Abstract
Serum levels of soluble tumor necrosis factor alpha receptor I (sTNF-RI) were elevated in patients with lepromatous (LL) reactional-state type II leprosy, and sTNF-RII levels were increased in patients with full tuberculoid (TT) or LL type II leprosy. The sTNF-R in sera from patients with type II leprosy, but not other forms of leprosy, inhibited recombinant TNF cytolytic activities in vitro. This suggests that sTNF-R regulatory activities are partially impaired in patients with leprosy.
摘要
在瘤型（LL）Ⅱ型麻风反应状态患者中，血清可溶性肿瘤坏死因子α受体I（sTNF-RI）水平升高，而在纯结核样型（TT）或LLⅡ型麻风患者中，sTNF-RII水平升高。Ⅱ型麻风患者血清中的sTNF-R（而非其他形式麻风患者血清中的sTNF-R）在体外可抑制重组TNF的细胞溶解活性。这表明麻风患者的sTNF-R调节活性部分受损。
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