α干扰素（IFN-α）对爱泼斯坦-巴尔病毒介导的CD21/CR2封端的抑制作用：IFN-α在感染早期的即时抗病毒活性。
Inhibition of Epstein-Barr virus-mediated capping of CD21/CR2 by alpha interferon (IFN-alpha): immediate antiviral activity of IFN-alpha during the early phase of infection.
作者信息
Delcayre A X, Lotz M, Lernhardt W
机构信息
California Institute of Biological Research, La Jolla.
出版信息
J Virol. 1993 May;67(5):2918-21. doi: 10.1128/JVI.67.5.2918-2921.1993.
Abstract
Early events of human B-lymphocyte infection by Epstein-Barr virus involve the virus binding to CD21, capping, and subsequent internalization of the virus-receptor complex. We show here that alpha interferon (IFN-alpha) inhibits the capping of Epstein-Barr virus-CD21 complexes. Synthetic peptides with the CD21 binding motif of IFN-alpha mimic IFN-alpha activity, suggesting that this effect may be mediated by IFN-alpha-CD21 interaction. Our findings demonstrate a novel and immediate mechanism of IFN-alpha action.
摘要
爱泼斯坦-巴尔病毒感染人类B淋巴细胞的早期事件包括病毒与CD21结合、形成帽状结构以及随后病毒-受体复合物的内化。我们在此表明，α干扰素（IFN-α）可抑制爱泼斯坦-巴尔病毒-CD21复合物的帽状结构形成。具有IFN-α的CD21结合基序的合成肽模拟了IFN-α的活性，提示这种效应可能由IFN-α与CD21的相互作用介导。我们的发现证明了IFN-α作用的一种新的直接机制。
相似文献
1
Inhibition of Epstein-Barr virus-mediated capping of CD21/CR2 by alpha interferon (IFN-alpha): immediate antiviral activity of IFN-alpha during the early phase of infection.α干扰素（IFN-α）对爱泼斯坦-巴尔病毒介导的CD21/CR2封端的抑制作用：IFN-α在感染早期的即时抗病毒活性。
J Virol. 1993 May;67(5):2918-21. doi: 10.1128/JVI.67.5.2918-2921.1993.
2
The Epstein-Barr virus-binding site on CD21 is involved in CD23 binding and interleukin-4-induced IgE and IgG4 production by human B cells.CD21上的爱泼斯坦-巴尔病毒结合位点参与CD23结合以及人B细胞中白细胞介素-4诱导的IgE和IgG4产生。
Immunology. 1996 May;88(1):35-9. doi: 10.1046/j.1365-2567.1996.d01-651.x.
3
Epstein Barr virus/complement C3d receptor is an interferon alpha receptor.爱泼斯坦-巴尔病毒/补体C3d受体是一种α干扰素受体。
EMBO J. 1991 Apr;10(4):919-26. doi: 10.1002/j.1460-2075.1991.tb08025.x.
4
Human lymphocytes shed a soluble form of CD21 (the C3dg/Epstein-Barr virus receptor, CR2) that binds iC3b and CD23.人类淋巴细胞可释放一种可溶性形式的CD21（C3dg/爱泼斯坦-巴尔病毒受体，CR2），该受体可结合iC3b和CD23。
Eur J Immunol. 1996 Jul;26(7):1497-503. doi: 10.1002/eji.1830260714.
5
Analysis of host gene expression changes reveals distinct roles for the cytoplasmic domain of the Epstein-Barr virus receptor/CD21 in B-cell maturation, activation, and initiation of virus infection.分析宿主基因表达变化揭示了 Epstein-Barr 病毒受体/CD21 的细胞质结构域在 B 细胞成熟、激活和病毒感染起始中的不同作用。
J Virol. 2014 May;88(10):5559-77. doi: 10.1128/JVI.03099-13. Epub 2014 Mar 5.
6
Soluble recombinant CR2 (CD21) inhibits Epstein-Barr virus infection.可溶性重组CR2（CD21）可抑制爱泼斯坦-巴尔病毒感染。
J Virol. 1990 Mar;64(3):1348-52. doi: 10.1128/JVI.64.3.1348-1352.1990.
7
Inhibition of Epstein-Barr virus infection in vitro and in vivo by soluble CR2 (CD21) containing two short consensus repeats.含两个短共有重复序列的可溶性CR2（CD21）在体外和体内对爱泼斯坦-巴尔病毒感染的抑制作用
J Virol. 1991 Jul;65(7):3559-65. doi: 10.1128/JVI.65.7.3559-3565.1991.
8
Epstein-Barr viruses that express a CD21 antibody provide evidence that gp350's functions extend beyond B-cell surface binding.表达 CD21 抗体的 Epstein-Barr 病毒提供了证据，证明 gp350 的功能超出了 B 细胞表面结合。
J Virol. 2010 Jan;84(2):1139-47. doi: 10.1128/JVI.01953-09. Epub 2009 Nov 4.
9
Determination of the role for CD21 during Epstein-Barr virus infection of B-lymphoblastoid cells.确定CD21在B淋巴母细胞爱泼斯坦-巴尔病毒感染过程中的作用。
J Virol. 1994 Aug;68(8):4716-26. doi: 10.1128/JVI.68.8.4716-4726.1994.
10
Binding sites of the Epstein-Barr virus and C3d receptor (CR2, CD21) for its three intracellular ligands, the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein.
Mol Immunol. 1995 Apr;32(6):389-97. doi: 10.1016/0161-5890(95)00005-y.
引用本文的文献
1
The fixation of complement protein pairs to CR2 isoforms.补体蛋白对与CR2亚型的结合。
Biochem Biophys Rep. 2024 Feb 10;38:101657. doi: 10.1016/j.bbrep.2024.101657. eCollection 2024 Jul.
2
Epstein-Barr Virus (EBV) Tegument Protein BGLF2 Suppresses Type I Interferon Signaling To Promote EBV Reactivation.EBV 衣壳蛋白 BGLF2 抑制 I 型干扰素信号通路以促进 EBV 再激活。
J Virol. 2020 May 18;94(11). doi: 10.1128/JVI.00258-20.
3
Latency type-dependent modulation of Epstein-Barr virus-encoded latent membrane protein 1 expression by type I interferons in B cells.Ⅰ型干扰素对 B 细胞中 Epstein-Barr 病毒编码的潜伏膜蛋白 1 表达的潜伏期类型依赖性调节。
J Virol. 2012 Apr;86(8):4701-7. doi: 10.1128/JVI.06829-11. Epub 2012 Feb 15.
4
Biophysical investigations of complement receptor 2 (CD21 and CR2)-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair.生物物理研究表明，补体受体 2（CD21 和 CR2）-配体相互作用揭示了每个受体-配体对的独特氨基酸接触。
J Biol Chem. 2010 Aug 27;285(35):27251-27258. doi: 10.1074/jbc.M110.106617. Epub 2010 Jun 17.
5
Complement receptors regulate lipopolysaccharide-induced T-cell stimulation.补体受体调节脂多糖诱导的T细胞刺激。
Immunology. 2005 Apr;114(4):493-8. doi: 10.1111/j.1365-2567.2004.02113.x.
6
Alpha interferon inhibits human herpesvirus 8 (HHV-8) reactivation in primary effusion lymphoma cells and reduces HHV-8 load in cultured peripheral blood mononuclear cells.α干扰素可抑制原发性渗出性淋巴瘤细胞中的人疱疹病毒8（HHV-8）激活，并降低培养的外周血单个核细胞中的HHV-8载量。
J Virol. 1999 May;73(5):4029-41. doi: 10.1128/JVI.73.5.4029-4041.1999.
7
Interferon-alpha and its effects on post-transplant lymphoproliferative disorders.α干扰素及其对移植后淋巴细胞增生性疾病的影响。
Springer Semin Immunopathol. 1998;20(3-4):425-36. doi: 10.1007/BF00838053.
8
Virus receptors: implications for pathogenesis and the design of antiviral agents.病毒受体：对发病机制及抗病毒药物设计的影响
Clin Microbiol Rev. 1995 Apr;8(2):293-315. doi: 10.1128/CMR.8.2.293.
9
Blocking of retroviral infection at a step prior to reverse transcription in cells transformed to constitutively express interferon beta.在组成型表达干扰素β的转化细胞中，在逆转录之前的步骤阻断逆转录病毒感染。
Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2689-93. doi: 10.1073/pnas.91.7.2689.
本文引用的文献
1
VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA.来自伯基特淋巴瘤的培养淋巴细胞中的病毒颗粒
Lancet. 1964 Mar 28;1(7335):702-3. doi: 10.1016/s0140-6736(64)91524-7.
2
Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines.淋巴结病相关病毒（LAV）适应于在EB病毒转化的B淋巴母细胞系中复制。
Science. 1984 Jul 6;225(4657):63-6. doi: 10.1126/science.6328661.
3
Replication of Epstein-Barr virus in human epithelial cells infected in vitro.爱泼斯坦-巴尔病毒在体外感染的人上皮细胞中的复制。
Nature. 1983;306(5942):480-3. doi: 10.1038/306480a0.
4
Immune deficiency in the X-linked lymphoproliferative syndrome. I. Epstein-Barr virus-specific defects.X连锁淋巴增殖综合征中的免疫缺陷。I. 爱泼斯坦-巴尔病毒特异性缺陷。
J Immunol. 1982 Dec;129(6):2532-5.
5
Interferon-mediated inhibition of virus penetration.干扰素介导的病毒穿透抑制作用。
Proc Natl Acad Sci U S A. 1983 Feb;80(4):1083-6. doi: 10.1073/pnas.80.4.1083.
6
Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.人类B淋巴细胞的爱泼斯坦-巴尔病毒受体是C3d受体CR2。
Proc Natl Acad Sci U S A. 1984 Jul;81(14):4510-4. doi: 10.1073/pnas.81.14.4510.
7
Relation of Burkitt's tumor-associated herpes-ytpe virus to infectious mononucleosis.伯基特淋巴瘤相关疱疹病毒与传染性单核细胞增多症的关系。
Proc Natl Acad Sci U S A. 1968 Jan;59(1):94-101. doi: 10.1073/pnas.59.1.94.
8
The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA.鼻咽癌的分化型含有EB病毒DNA。
Int J Cancer. 1987 Jan 15;39(1):25-9. doi: 10.1002/ijc.2910390106.
9
Model for studying virus attachment: identification and quantitation of Epstein-Barr virus-binding cells by using biotinylated virus in flow cytometry.病毒附着研究模型：利用生物素化病毒通过流式细胞术鉴定和定量爱泼斯坦-巴尔病毒结合细胞
J Virol. 1988 Jul;62(7):2453-63. doi: 10.1128/JVI.62.7.2453-2463.1988.
10
Regulation of Epstein-Barr virus infection by recombinant interferons. Selected sensitivity to interferon-gamma.重组干扰素对爱泼斯坦-巴尔病毒感染的调节作用。对干扰素-γ的特定敏感性。
Eur J Immunol. 1985 May;15(5):520-5. doi: 10.1002/eji.1830150518.
Zotero 插件