Ⅰ型干扰素对 B 细胞中 Epstein-Barr 病毒编码的潜伏膜蛋白 1 表达的潜伏期类型依赖性调节。
Latency type-dependent modulation of Epstein-Barr virus-encoded latent membrane protein 1 expression by type I interferons in B cells.
机构信息
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
出版信息
J Virol. 2012 Apr;86(8):4701-7. doi: 10.1128/JVI.06829-11. Epub 2012 Feb 15.
Abstract
We report that type I interferons (IFNs) upregulate latent membrane protein 1 (LMP-1) expression by direct activation of the ED-L1 promoter in several Epstein-Barr virus (EBV)-carrying Burkitt's lymphoma lines. In EBV-infected primary B cells, IFN-α transiently upregulates LMP-1 mRNA, but not protein levels, followed by downregulation of both, suggesting a novel antiproliferative mechanism of type I IFNs. Furthermore, our results may explain the expression of LMP-1 in memory B cells of systemic lupus erythematosus patients.
摘要
我们报告称，I 型干扰素（IFNs）通过直接激活 Epstein-Barr 病毒（EBV）携带的 Burkitt 淋巴瘤系中的 ED-L1 启动子，上调潜伏膜蛋白 1（LMP-1）的表达。在 EBV 感染的原代 B 细胞中，IFN-α 短暂地上调 LMP-1 mRNA，但不影响蛋白水平，随后两者均下调，提示 I 型 IFNs 的一种新的抗增殖机制。此外，我们的结果可能解释了系统性红斑狼疮患者记忆 B 细胞中 LMP-1 的表达。
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