Coates A L, Bergsteinsson H, Desmond K, Outerbridge E W, Beaudry P H
J Pediatr. 1977 Apr;90(4):611-6. doi: 10.1016/s0022-3476(77)80382-x.
Seven children born prematurely who survived the respiratory distress syndrome, seven children born prematurely who had no neonatal lung disease, and seven normal children born at term were studied by comparison of flow volume curves obtained while breathing air to those obtained while breathing 80% helium and 20% oxygen. Expiratory flow rates in air both groups of prematurely born children were lower than flow rates of the children born at term, and the volumes of iso-flow were higher in the survivors of RDS than those of the children born at term. The differences in flow rates in air suggest an increase in large airway resistance in both groups of prematurely born children. It is speculated that this may be secondary to growth retardation related to prematurity. The elevated Viso V in the RDS group suggests an increase in small airway resistance secondary to the disease or to its therapy.
对七名患有呼吸窘迫综合征并存活下来的早产儿童、七名无新生儿肺部疾病的早产儿童以及七名足月出生的正常儿童进行了研究，比较了他们呼吸空气时和呼吸80%氦气与20%氧气时获得的流量-容积曲线。两组早产儿童呼吸空气时的呼气流量率均低于足月出生儿童的流量率，呼吸窘迫综合征幸存者的等流量容积高于足月出生儿童。呼吸空气时流量率的差异表明两组早产儿童的大气道阻力均增加。据推测，这可能继发于与早产相关的生长迟缓。呼吸窘迫综合征组中升高的等流量容积表明，该疾病或其治疗导致小气道阻力增加。
