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来自猕猴桃相关真菌的3-十氢化萘酰基四嗪酸及其对……的抗菌活性

3-Decalinoyltetramic acids from kiwi-associated fungus sp. and their antibacterial activity against .

作者信息

Yi Xue-Wen, He Juan, Sun Li-Tang, Liu Ji-Kai, Wang Guo-Kai, Feng Tao

机构信息

School of Pharmacy, Anhui University of Chinese Medicine, Anhui Key Laboratory of Modern Chinese Materia Medica Hefei 230012 People's Republic of China

School of Pharmaceutical Sciences, South-Central University for Nationalities Wuhan 430074 People's Republic of China.

出版信息

RSC Adv. 2021 May 25;11(31):18827-18831. doi: 10.1039/d1ra02120f. eCollection 2021 May 24.

DOI:10.1039/d1ra02120f
PMID:35478665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9033601/
Abstract

Four rare 3-decalinoyltetramic acid derivatives, zofielliamides A-D (1-4), were obtained from cultures of kiwi-associated fungus sp. Their structures with absolute configurations were established by extensive spectroscopic methods and single crystal X-ray diffraction. The compounds possessed rare pentacyclic systems that might derive from a polyene precursor [4 + 2] intramolecular Diels-Alder reactions. Compounds 1, 2, and 4 showed antibacterial activity against plant pathogen with MIC values of 64, 32, and 64 μg mL, respectively.

摘要

从与猕猴桃相关的真菌菌株的培养物中获得了四种罕见的3-癸酰基四嗪酸衍生物，即佐菲酰胺A-D（1-4）。通过广泛的光谱方法和单晶X射线衍射确定了它们具有绝对构型的结构。这些化合物具有罕见的五环体系，可能源自多烯前体的[4 + 2]分子内狄尔斯-阿尔德反应。化合物1、2和4对植物病原菌显示出抗菌活性，其最低抑菌浓度（MIC）值分别为64、32和64μg/mL。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74bf/9033601/60d5b1c45f52/d1ra02120f-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74bf/9033601/b1abaaafb1d9/d1ra02120f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74bf/9033601/46b6615f5103/d1ra02120f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74bf/9033601/6685b83c6c0c/d1ra02120f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74bf/9033601/ccba1f25efb6/d1ra02120f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74bf/9033601/a45d96d4ddfa/d1ra02120f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74bf/9033601/60d5b1c45f52/d1ra02120f-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74bf/9033601/b1abaaafb1d9/d1ra02120f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74bf/9033601/46b6615f5103/d1ra02120f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74bf/9033601/6685b83c6c0c/d1ra02120f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74bf/9033601/ccba1f25efb6/d1ra02120f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74bf/9033601/a45d96d4ddfa/d1ra02120f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74bf/9033601/60d5b1c45f52/d1ra02120f-f6.jpg

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