Savonenko A V, Prokop'eva V D
Biull Eksp Biol Med. 1993 Jun;115(6):631-2.
The relationship of Na,K-ATPase of erythrocytes and MgCl2 concentration in the incubation medium was studied in rats preferring ethanol (PE) and rejecting ethanol (RE) normally and 3 months after chronic alcoholization. The dependence of erythrocyte Na,K-ATPase on MgCl2 in PE and RE animals before alcoholization was similar. The chronic effect of alcohol on rats resulted in increase of Na,K-ATPase both in PE and RE rats; however, Mg(2+)-dependence of increase of Na,K-ATPase differed in animals with different response to alcohol: in PE rats, the per cent of increasing activity of Na,K-ATPase declined with the growth of MgCl2 concentration and in RE rats increased. It is concluded that the reaction to alcohol of the functional activity of plasma membranes differs in rats with different alcohol motivation.
研究了正常情况下偏好乙醇（PE）和排斥乙醇（RE）的大鼠以及慢性酒精化3个月后的大鼠红细胞钠钾-ATP酶与孵育介质中氯化镁浓度的关系。酒精化前，PE和RE动物红细胞钠钾-ATP酶对氯化镁的依赖性相似。酒精对大鼠的慢性作用导致PE和RE大鼠的钠钾-ATP酶均增加；然而，不同酒精反应动物中钠钾-ATP酶增加的镁离子依赖性不同：在PE大鼠中，钠钾-ATP酶活性增加的百分比随氯化镁浓度的升高而下降，而在RE大鼠中则增加。得出结论：不同酒精动机的大鼠对酒精的质膜功能活性反应不同。
