大鼠发育过程中血浆铜和锌的变化。

Changes in plasma copper and zinc during rat development.

作者信息

Martínez Lista E, Solé J, Arola L, Mas A

机构信息

Universitat Rovira i Virgili, Departamento Bioquímica i Biotecnologia, Tarragona, Espanya.

出版信息

Biol Neonate. 1993;64(1):47-52. doi: 10.1159/000243969.

DOI:10.1159/000243969

PMID:8399799

Abstract

The association of copper and zinc to plasma ligands was studied during the rat perinatal period. Analysis was carried out by means of column chromatography (Sephadex G-150) and atomic absorption spectrophotometry. Levels of copper were low at birth and showed a sharp increase after day 10. This increase was similar to that of ceruloplasmin activity as well as its association with copper. Zinc levels, instead, showed higher levels before birth and decreased slowly toward the adult values. Association of zinc to albumin and associated proteins showed a pattern similar to the decrease in plasma zinc levels.

摘要

在大鼠围产期研究了铜和锌与血浆配体的关联。通过柱色谱法（葡聚糖凝胶G - 150）和原子吸收分光光度法进行分析。出生时铜水平较低，出生后第10天急剧上升。这种上升与铜蓝蛋白活性及其与铜的关联相似。相反，锌水平在出生前较高，并朝着成年值缓慢下降。锌与白蛋白及相关蛋白质的关联呈现出与血浆锌水平下降相似的模式。