Brookshier K A, Tarbell J M
Department of Chemical Engineering, Pennsylvania State University, University Park 16802.
Biorheology. 1993 Mar-Apr;30(2):107-16. doi: 10.3233/bir-1993-30202.
Aqueous solutions of Xanthan gum and glycerin were developed that match both the viscous and elastic components of the 2 Hz complex viscosity of blood over a broad range of shear rates (1-1000 s-1) and hematocrits (20%-80%). Measurements of wall shear rate in pulsatile flow were conducted in straight and atherogenic curved artery models using both the blood analog fluid and blood to compare their flow behavior. Peak wall shear rates determined in these models under nearly identical flow conditions with the two fluids were not statistically different (p > 0.05). These results indicate that aqueous Xanthan gum/glycerin solutions provide a good blood analog fluid for flow conditions characteristic of large arteries. Because the fluid is transparent and made from readily available and fairly inexpensive materials, it may be generally useful for in vitro hemodynamic studies, particularly those employing optical techniques.
开发了黄原胶和甘油的水溶液，在很宽的剪切速率范围（1 - 1000 s-1）和血细胞比容范围（20% - 80%）内，该溶液能匹配血液在2 Hz时复数粘度的粘性和弹性成分。使用血液模拟液和血液，在直管和致动脉粥样硬化的弯曲动脉模型中进行了脉动流壁面剪切速率的测量，以比较它们的流动行为。在几乎相同的流动条件下，用这两种流体在这些模型中确定的峰值壁面剪切速率没有统计学差异（p > 0.05）。这些结果表明，黄原胶水溶液/甘油溶液为大动脉特征性流动条件提供了一种良好的血液模拟液。由于该流体是透明的，且由容易获得且相当便宜的材料制成，它可能普遍适用于体外血液动力学研究，特别是那些采用光学技术的研究。
