Tomlin J, Brown N, Ellis A, Carlsson A, Bogentoft C, Read N W
Centre for Human Nutrition, Northern General Hospital, Sheffield.
Gut. 1993 Sep;34(9):1177-81. doi: 10.1136/gut.34.9.1177.
A combination of the polysaccharide ethyl-hydroxyethyl-cellulose (EHEC) and the surfactant sodium-dodecylsulphate (SDS) has the extraordinary physical property of being liquid at room temperature but gelling firmly at 37 degrees C. It has been named 'liquid fibre' and its effect on gastric emptying has been tested in rats and humans, as well as its effect on intestinal distribution in rats. Rats were gavaged with 5 ml of radiolabelled liquid fibre, SDS in water, or water control. Subgroups were killed after 25, 50, 100, 200, and 300 minutes, the gut removed, and the distribution of radioactivity measured scintigraphically. Liquid fibre gelled in the stomach and spread exponentially down the small intestine before 25 minutes. This distribution was maintained for 200 minutes after which the stomach began to empty again. In the human study, 10 healthy men drank 250 ml liquid fibre and placebo labelled with 1.85 MBq technetium tin colloid on separate occasions. Gastric emptying was measured by gamma-camera. Half emptying time significantly increased from 17.7 to 55.8 minutes (means, p < 0.05). The time for 10% to empty (which includes any lag time) increased from 7.0 to 19.4 minutes (p < 0.05). Average emptying rate decreased from 4.49%/min for placebo to 1.60%/min for liquid fibre (p < 0.01). The dramatic delay in gastric emptying suggests liquid fibre may have clinical applications while its liquid formulation should improve acceptability.
多糖乙基羟乙基纤维素（EHEC）与表面活性剂十二烷基硫酸钠（SDS）的组合具有非凡的物理特性，即在室温下呈液态，但在37摄氏度时会牢固地凝胶化。它被命名为“液体纤维”，其对胃排空的影响已在大鼠和人类中进行了测试，以及其对大鼠肠道分布的影响。给大鼠灌胃5毫升放射性标记的液体纤维、水中的SDS或水对照。在25、50、100、200和300分钟后处死亚组，取出肠道，并通过闪烁显像法测量放射性分布。液体纤维在胃中凝胶化，并在25分钟前呈指数形式向下扩散至小肠。这种分布维持了200分钟，之后胃又开始排空。在人体研究中，10名健康男性在不同时间分别饮用250毫升标记有1.85兆贝可锝锡胶体的液体纤维和安慰剂。通过γ相机测量胃排空情况。半排空时间从17.7分钟显著增加到55.8分钟（平均值，p<0.05）。10%排空时间（包括任何延迟时间）从7.0分钟增加到19.4分钟（p<0.05）。平均排空率从安慰剂的4.49%/分钟降至液体纤维的1.60%/分钟（p<0.01）。胃排空的显著延迟表明液体纤维可能具有临床应用价值，而其液体剂型应能提高可接受性。
