Scott A M, Kellow J E, Shuter B, Nolan J M, Hoschl R, Jones M P
Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia.
Gastroenterology. 1993 Feb;104(2):410-6. doi: 10.1016/0016-5085(93)90408-5.
The acute effects of cigarette smoking on gastric emptying are controversial, whereas its effects on the intragastric distribution of solids and liquids are not established.
Dual isotope gastric scintigraphy was performed in 15 habitual smokers (studied twice, either sham smoking or actively smoking) and in 15 age- and sex-matched nonsmokers.
Acute smoking was associated with an increased prevalence of episodes of retrograde intragastric movement of solids (3 of 15 sham subjects vs. 12 of 15 actively smoking subjects; P < 0.01) and of liquids (0 of 15 vs. 7 of 15; P < 0.01) from distal to proximal stomach. Fundal half-emptying time (T1/2) for liquids was also prolonged by smoking (43 +/- 19 minutes sham vs. 125 +/- 216 minutes active; P < 0.05). Acute smoking delayed solid lag time (13 +/- 6 minutes sham vs. 32 +/- 18 active; P < 0.05) and liquid T1/2 (46 +/- 21 vs. 90 +/- 50 minutes; P < 0.05). In the nonsmokers, such episodes of proximal intragastric redistribution did not occur, and intragastric and overall emptying parameters did not differ significantly from those of habitual sham smokers.
Acute cigarette smoking produces excessive antrofundal redistribution of both solid and liquid contents and delays solid and liquid gastric emptying.
吸烟对胃排空的急性影响存在争议，而其对胃内固体和液体分布的影响尚不明确。
对15名习惯性吸烟者（进行两次研究，分别为假吸烟或主动吸烟）和15名年龄及性别匹配的非吸烟者进行双同位素胃闪烁扫描。
急性吸烟与固体从胃远端向近端逆行胃内移动发作的发生率增加相关（15名假吸烟受试者中有3名，15名主动吸烟受试者中有12名；P<0.01），液体从胃远端向近端逆行胃内移动发作的发生率也增加（15名中有0名，15名中有7名；P<0.01）。吸烟还延长了液体的胃底半排空时间（T1/2）（假吸烟为43±19分钟，主动吸烟为125±216分钟；P<0.05）。急性吸烟延迟了固体滞后时间（假吸烟为13±6分钟，主动吸烟为32±18分钟；P<0.05）和液体T1/2（46±21分钟对90±50分钟；P<0.05）。在非吸烟者中，未发生这种胃近端再分布发作，胃内和总体排空参数与习惯性假吸烟者相比无显著差异。
急性吸烟导致胃窦部和胃底部固体和液体内容物过度重新分布，并延迟固体和液体胃排空。
