Collins P J, Horowitz M, Maddox A, Myers J C, Chatterton B E
Department of Nuclear Medicine, Royal Adelaide Hospital, Australia.
Am J Physiol. 1996 Oct;271(4 Pt 1):G549-54. doi: 10.1152/ajpgi.1996.271.4.G549.
This study evaluated the hypothesis that an increase in the volume of the solid component of a mixed solid/nutrient liquid meal will result in more rapid emptying of the solid but slower liquid emptying. Eight normal volunteers were studied on two occasions after ingesting a meal containing 150 ml of 10% dextrose with either 100 g(small) or 400 g (large) of ground beef. Subjects ingested the solid component before the liquid. For the solid component, the lag phase was longer for the larger meal (56 vs. 31 min, P < 0.001). However, the absolute emptying rate for the proximal stomach and the postlag emptying rate of solid from the total stomach, when expressed as kilocalories per minute, were greater with the larger meal (P < 0.002). The lag phase was prolonged (P < 0.03) and the rate of emptying of liquid from the total and proximal stomach was slower (P < 0.001) in the large compared with the small meal. The total amount of energy delivered to the duodenum (from solid and liquid components) after the solid lag phase was greater for the larger meal (4.8 vs. 2.5 kcal/min, P < 0.002). These results indicate that an increase in the volume of the solid component of a mixed solid/liquid meal 1) prolongs the lag phase but accelerates the postlag emptying rate of solid and 2) retards intragastric distribution and emptying of liquid.
混合固体/营养液餐中固体成分体积增加会导致固体排空更快，但液体排空更慢。八名正常志愿者在摄入含有150毫升10%葡萄糖以及100克（小份）或400克（大份）绞碎牛肉的餐食后，分两次接受研究。受试者先摄入固体成分，后摄入液体成分。对于固体成分，大份餐食的延迟期更长（56分钟对31分钟，P<0.001）。然而，以每分钟千卡数表示时，大份餐食近端胃的绝对排空率以及固体从整个胃的延迟后排空率更高（P<0.002）。与小份餐食相比，大份餐食的延迟期延长（P<0.03），液体从整个胃和近端胃的排空速度更慢（P<0.001）。固体延迟期后输送到十二指肠的总能量（来自固体和液体成分），大份餐食更多（4.8千卡/分钟对2.5千卡/分钟，P<0.002）。这些结果表明，混合固体/液体餐中固体成分体积增加：1）会延长延迟期，但会加速固体延迟后的排空率；2）会延迟胃内液体的分布和排空。
