Samonis G, Gikas A, Anaissie E J, Vrenzos G, Maraki S, Tselentis Y, Bodey G P
Department of Medical Oncology, University of Crete, Heraklion, Greece.
Antimicrob Agents Chemother. 1993 Jan;37(1):51-3. doi: 10.1128/AAC.37.1.51.
This study evaluated the effects of broad-spectrum antibiotics on the gastrointestinal (G.I.) yeast flora of humans and correlated the findings with those obtained from a mouse model of G.I. colonization by Candida albicans. We prospectively studied 46 adult cancer patients who received one of five broad-spectrum antibiotics (ceftriaxone, ceftazidime, ticarcillin-clavulanic acid, imipenem-cilastatin, and aztreonam) as therapy for infections. Quantitative examination of yeast colonization of stools was conducted at the baseline, at the end of antibiotic treatment, and 1 week after discontinuation of therapy. Antibiotics with anaerobic activity (ticarcillin-clavulanic acid) or high G.I. concentrations (ceftriaxone) caused a higher and more sustained increase in G.I. colonization by yeasts than did antibiotics with poor anaerobic activity (ceftazidime and aztreonam) or a low G.I. concentration (imipenem-cilastatin). These results were similar to those obtained with a mouse model of G.I. colonization by C. albicans that involved the same antibiotics. Hence, the mouse model may be useful for evaluation of yeast colonization of the human G.I. tract.
本研究评估了广谱抗生素对人类胃肠道酵母菌群的影响，并将研究结果与白色念珠菌胃肠道定植小鼠模型的结果进行关联。我们前瞻性地研究了46例成年癌症患者，这些患者接受了五种广谱抗生素（头孢曲松、头孢他啶、替卡西林-克拉维酸、亚胺培南-西司他丁和氨曲南）中的一种作为感染治疗药物。在基线、抗生素治疗结束时以及停药1周后，对粪便中的酵母定植进行定量检测。具有厌氧活性的抗生素（替卡西林-克拉维酸）或胃肠道高浓度抗生素（头孢曲松），相比于厌氧活性差的抗生素（头孢他啶和氨曲南）或胃肠道低浓度抗生素（亚胺培南-西司他丁），会导致胃肠道酵母定植出现更高且更持久的增加。这些结果与白色念珠菌胃肠道定植小鼠模型使用相同抗生素所获得的结果相似。因此，该小鼠模型可能有助于评估人类胃肠道的酵母定植情况。
