Breban M A, Moreau M C, Fournier C, Ducluzeau R, Kahn M F
INSERM U. 283, Hôpital Cochin, Paris, France.
Clin Exp Rheumatol. 1993 Jan-Feb;11(1):61-4.
Collagen-induced arthritis is an experimental model for rheumatoid arthritis which can be elicited in susceptible strains of rats by intradermal injection of native type II collagen. In order to investigate whether bacterial flora may alter the pathogenic response to type II collagen, we have immunized germ-free (GF) male rats from either highly resistant Fisher (F344) or highly susceptible Dark Agouti (DA) strains. The disease was markedly enhanced in GF DA as compared to conventional (CV) DA rats. The humoral response was also stronger in GF rats of both strains. Neither GF nor CV F344 developed arthritis, although GF F344 exhibited later inflammation of the tail. These data support a suppressive influence of bacterial flora on collagen-induced arthritis.
胶原诱导性关节炎是类风湿性关节炎的一种实验模型，通过皮内注射天然II型胶原可在易感大鼠品系中诱发。为了研究细菌菌群是否会改变对II型胶原的致病反应，我们对来自高度抗性的费希尔（F344）或高度易感的黑豚鼠（DA）品系的无菌（GF）雄性大鼠进行了免疫。与常规（CV）DA大鼠相比，GF DA大鼠的病情明显加重。两个品系的GF大鼠的体液反应也更强。尽管GF F344大鼠尾部出现了后期炎症，但GF和CV F344大鼠均未发生关节炎。这些数据支持细菌菌群对胶原诱导性关节炎具有抑制作用。
