Nyström E, Bengtsson C, Lapidus L, Petersen K, Lindstedt G
Department of Medicine, Sahlgren's Hospital, University of Göteborg, Sweden.
J Endocrinol Invest. 1993 Feb;16(2):129-31. doi: 10.1007/BF03347665.
Smoking is associated with a spectrum of disorders. Recent reports have shown decreased serum concentrations of thyrotropin in euthyroid smokers, and there is an association between smoking and development of goiter (toxic and euthyroid). In a 12-year follow-up of a randomly selected sample of women we found a strong association between smoking at the time of initial screening and later development of hypothyroidism, the relative risk for a female smoker to develop hypothyroidism being 3.9 (95% confidence interval 1.6-9.1). There was, however, no association between smoking habits at the end of the follow-up and hypothyroidism. This indicates that several women who developed hypothyroidism may have done so in association with a change in smoking habits.
吸烟与一系列疾病有关。最近的报告显示，甲状腺功能正常的吸烟者血清促甲状腺激素浓度降低，并且吸烟与甲状腺肿（毒性和非毒性）的发生之间存在关联。在对随机抽取的女性样本进行的12年随访中，我们发现初次筛查时吸烟与后来发生甲状腺功能减退症之间存在强烈关联，女性吸烟者发生甲状腺功能减退症的相对风险为3.9（95%置信区间1.6 - 9.1）。然而，随访结束时的吸烟习惯与甲状腺功能减退症之间没有关联。这表明，一些发生甲状腺功能减退症的女性可能是与吸烟习惯的改变有关。
