Evans M S, Reid K H, Sharp J B
Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield.
Neurosci Lett. 1993 Feb 19;150(2):145-8. doi: 10.1016/0304-3940(93)90522-m.
Dimethylsulfoxide (DMSO) is readily absorbed through skin, and relieves musculoskeletal pain when applied topically to painful areas. We studied the effects of DMSO on C-type nerve fibers, which mediate pain sensation. DMSO was applied directly to exposed cat sural nerves. C fiber conduction velocity was slowed by DMSO, even in low concentrations (5-7% v/v). Higher concentrations completely blocked C fiber conduction, with a minimum blocking concentration of 9%. Onset of nerve block was almost immediate with 15% DMSO or higher concentrations. C fiber blockade may account for analgesia with DMSO.
二甲基亚砜（DMSO）很容易通过皮肤吸收，局部应用于疼痛部位时可缓解肌肉骨骼疼痛。我们研究了DMSO对介导疼痛感觉的C型神经纤维的影响。将DMSO直接应用于暴露的猫腓肠神经。即使在低浓度（5-7%体积/体积）下，DMSO也会使C纤维传导速度减慢。更高的浓度会完全阻断C纤维传导，最小阻断浓度为9%。使用15% DMSO或更高浓度时，神经阻滞几乎立即起效。C纤维阻滞可能是DMSO产生镇痛作用的原因。
