Kahn E M, Weiner R D, Coppola R, Kudler H S, Schultz K
Department of Psychiatry, Dartmouth Medical School, Hanover, NH.
Biol Psychiatry. 1993 Feb 15;33(4):284-90. doi: 10.1016/0006-3223(93)90296-p.
The authors performed spectral analysis of electroencephalograms (EEG), recorded awake, with eyes closed, in 13 patients with schizophrenia and 9 age-matched individuals without psychiatric diagnosis. We tested several possible parameterizations of the data, and two data-reduction strategies; these yielded similar results. Comparison of the two groups revealed a relative increase in alpha frequency activity in the frontal regions in the patient group. The authors believe that this finding is consistent with data from neuropsychologic tests, metabolic imaging studies, and evoked potential studies that suggest impaired activation of frontal brain areas in patients with schizophrenia.
作者对13例精神分裂症患者和9名年龄匹配的无精神疾病诊断个体在清醒、闭眼状态下记录的脑电图（EEG）进行了频谱分析。我们测试了数据的几种可能参数化方法以及两种数据简化策略；这些方法产生了相似的结果。两组比较显示，患者组额叶区域的α频率活动相对增加。作者认为，这一发现与神经心理学测试、代谢成像研究和诱发电位研究的数据一致，这些研究表明精神分裂症患者额叶脑区的激活受损。
