Buckland-Wright J C, Clarke G S, Chikanza I C, Grahame R
Division of Anatomy and Cell Biology, United Medical School of Guy's Hospital, London, UK.
J Rheumatol. 1993 Feb;20(2):243-7.
Patients with early rheumatoid arthritis (RA) were randomly divided into those receiving gold early (n = 13) or 6 months later (n = 10). They were followed 6 monthly over 18 months. Mean erosion area in gold and delayed gold, measured from macroradiographs, was comparable at baseline and increased significantly over the first 6 months. In the second 6 months, gold showed no increase and delayed gold an insignificant increase. By the third 6 months both groups showed a decrease. On comparing the second 6 months of gold therapy in gold and delayed gold with a group of patients with RA of similar disease duration (n = 34) not receiving gold, a lower proportion (p < 0.005) had erosion area progression and a higher proportion (p < 0.001) erosion repair.
早期类风湿性关节炎（RA）患者被随机分为两组，一组早期接受金制剂治疗（n = 13），另一组6个月后接受金制剂治疗（n = 10）。对他们进行为期18个月、每6个月一次的随访。从放大X线片测量得到的金制剂组和延迟金制剂组的平均侵蚀面积在基线时相当，且在最初6个月内显著增加。在第二个6个月，金制剂组无增加，延迟金制剂组有不显著增加。到第三个6个月，两组均出现下降。将金制剂组和延迟金制剂组金制剂治疗的第二个6个月与一组疾病病程相似未接受金制剂治疗的类风湿性关节炎患者（n = 34）进行比较，前者侵蚀面积进展的比例较低（p < 0.005），侵蚀修复的比例较高（p < 0.001）。
