双硫仑对1,2 - 二甲基肼代谢的抑制作用。

Inhibition of 1,2-dimethylhydrazine metabolism by disulfiram.

Fiala E S, Bobotas G, Kulakis C, Weisburger J H

Xenobiotica. 1977 Jan-Feb;7(1-2):5-9. doi: 10.3109/00498257709036240.

Abstract

The effects of disulfiram on the metabolism of 1,2-dimethylhydrazine were studied in CDF rats. 2. Treatment with disulfiram causes enhanced elimination of azomethane in the expired air, inhibition of CO2 production, and decreased levels of 1,2-dimethylhydrazine metabolites in the urine. 3. These results suggest that disulfiram inhibits the N-oxidation of azomethane to azoxymethane, thus preventing further metabolism to the ultimate carcinogenic species, and provide an explanation for the observations that disulfiram inhibits 1,2-dimethylhydrazine-induced neoplasia of the large intestine.

摘要

在CDF大鼠中研究了双硫仑对1,2 - 二甲基肼代谢的影响。2. 用双硫仑治疗可导致呼出气体中偶氮甲烷的消除增强、二氧化碳产生受到抑制以及尿液中1,2 - 二甲基肼代谢物水平降低。3. 这些结果表明，双硫仑抑制偶氮甲烷向氧化偶氮甲烷的N - 氧化，从而防止进一步代谢为最终致癌物质，并为双硫仑抑制1,2 - 二甲基肼诱导的大肠肿瘤形成的观察结果提供了解释。