Dinjus U, Steinbach G, Methner U, Hänel I, Schulze P U, Schweinitz P
Institut für Veterinärmedizin des Bundesgesundheitsamtes, (Robert von Ostertag-Institut), Bereich Jena.
Zentralbl Mikrobiol. 1993 Mar;148(2):95-102. doi: 10.1016/s0232-4393(11)80111-3.
Cell-free supernatants of 40 Salmonella strains of different serovars were tested for the existence of enterotoxic substances in the rabbit skin permeability factor test, rabbit ileal loop test, tissue culture assays (CHO K1, RTG-2), and baby mouse test. There were differences in the test results between the strains even within the same serovar. Correlation coefficients between the results of different toxin tests were low. It is therefore improbable that the "enterotoxic activity" of Salmonella is caused by only one toxic substance. The activities revealed in the different test systems could not be related to virulence or the epizootiological behaviour of the strains. The in vitro occurrence of the virulence factor "enterotoxin production" is lower for Salmonella than for E. coli and V. cholerae.
在兔皮通透性试验、兔回肠袢试验、组织培养试验（CHO K1、RTG - 2）和幼鼠试验中，对40株不同血清型沙门氏菌的无细胞上清液进行了肠毒素物质检测。即使在同一血清型内，不同菌株的检测结果也存在差异。不同毒素试验结果之间的相关系数较低。因此，沙门氏菌的“肠毒素活性”不太可能仅由一种有毒物质引起。在不同试验系统中显示的活性与菌株的毒力或流行病学行为无关。沙门氏菌毒力因子“产肠毒素”在体外的发生率低于大肠杆菌和霍乱弧菌。
