Maislos M, Khamaysi N, Assali A, Abou-Rabiah Y, Zvili I, Shany S
Department of Medicine, Tour Institute, Soroka Medical Center, Ben-Gurion University Faculty of Health Sciences, Beer Sheva, Israel.
Am J Clin Nutr. 1993 May;57(5):640-2. doi: 10.1093/ajcn/57.5.640.
We evaluated the effect of the Ramadan fasting on plasma lipids and lipoproteins in normal individuals. Twenty-four healthy subjects were studied before the end of the Ramadan month (Ram) and for 1 mo thereafter. Plasma total cholesterol (TC), triglycerides, low-density-lipoprotein cholesterol (LDL-C), and very-low-density-lipoprotein cholesterol (VLDL-C) did not change. High-density-lipoprotein cholesterol (HDL-C) was 30% higher (P < 0.005) at the end of Ram; apolipoprotein A-I also increased (P < 0.0001). Both the ratios of TC to HDL-C and LDL-C to HDL-C (P < 0.001) decreased at Ram. There was a striking nonpharmacologic improvement in plasma HDL-C and ratios of TC to HDL-C and LDL-C to HDL-C, which were most probably induced by eating one large evening meal a day. Further studies to determine the mechanism of this observation are underway.
我们评估了斋月禁食对正常个体血浆脂质和脂蛋白的影响。在斋月结束前（斋月期间）和之后的1个月内对24名健康受试者进行了研究。血浆总胆固醇（TC）、甘油三酯、低密度脂蛋白胆固醇（LDL-C）和极低密度脂蛋白胆固醇（VLDL-C）没有变化。斋月结束时高密度脂蛋白胆固醇（HDL-C）升高了30%（P<0.005）；载脂蛋白A-I也增加了（P<0.0001）。斋月期间TC与HDL-C的比值以及LDL-C与HDL-C的比值（P<0.001）均下降。血浆HDL-C以及TC与HDL-C的比值和LDL-C与HDL-C的比值有显著的非药物性改善，这很可能是由于每天晚餐量大所致。确定这一观察结果机制的进一步研究正在进行中。
