Luke S, Verma R S
Division of Genetics, Long Island College Hospital, SUNY Health Science Center, Brooklyn 11201.
Mol Gen Genet. 1993 Mar;237(3):460-2. doi: 10.1007/BF00279451.
Using a series of genetic parameters, attempts have been made for more than two decades to establish the close kinship of human (Homo sapiens) with chimpanzee (Pan troglodytes). Molecular and cytogenetic data presently suggest that the two species are closely related. The recent isolation of a human telomeric probe (P5097-B.5) has prompted us to cross hybridize it to chimpanzee chromosomes in order to explore convergence and/or divergence of the telomeric repeat sequences (TTAGGG)n. On hybridization, the human probe bound to both ends (telomeres) of chimpanzee chromosomes, suggesting a concerted evolution of tandemly repeated short simple sequences (TTAGGG)n. Even the terminal heterochromatin of chimpanzee chromosomes was found to be endowed with telomeric repeats, suggesting that evolution of heterochromatin and capping with tandemly repeated short sequences are highly complex phenomena.
二十多年来，人们一直试图利用一系列遗传参数来确定人类（智人）与黑猩猩（黑猩猩属）之间的密切亲缘关系。目前，分子和细胞遗传学数据表明这两个物种关系密切。最近分离出的一种人类端粒探针（P5097 - B.5）促使我们将其与黑猩猩染色体进行杂交，以探索端粒重复序列（TTAGGG）n的趋同和/或差异。杂交时，人类探针与黑猩猩染色体的两端（端粒）结合，表明串联重复短简单序列（TTAGGG）n存在协同进化。甚至发现黑猩猩染色体的末端异染色质也含有端粒重复序列，这表明异染色质的进化以及串联重复短序列的封端是高度复杂的现象。
