Karch H, Huppertz H I
Institute of Hygiene, University of Würzburg, Germany.
Rheumatol Int. 1993;12(6):227-9. doi: 10.1007/BF00301006.
In the pathogenesis of late Lyme borreliosis the relative importance of the causative organism, Borrelia burgdorferi, and the immune response of the host, including autoimmune phenomena, is not yet known. We describe a 7-year-old boy with Lyme arthritis from whom two synovial fluid samples were obtained 5 months apart and up to 17 months after the first appearance of arthritis. Both synovial fluid specimens were shown to contain borrelial DNA by nested polymerase chain reaction for the amplification of portions of the genes for flagellin and OspA. Thus, Borrelia burgdorferi may persist within the joint even during late stages of the disease.
在晚期莱姆病的发病机制中，致病微生物伯氏疏螺旋体以及宿主的免疫反应（包括自身免疫现象）的相对重要性尚不清楚。我们描述了一名患莱姆关节炎的7岁男孩，在关节炎首次出现后的5个月内以及长达17个月的时间里，分别采集了两份间隔5个月的滑液样本。通过巢式聚合酶链反应扩增鞭毛蛋白和外膜蛋白A基因的部分片段，两份滑液标本均显示含有伯氏疏螺旋体DNA。因此，即使在疾病的晚期，伯氏疏螺旋体也可能在关节内持续存在。
