Sommer A
Am J Ophthalmol. 1977 Mar;83(3):334-9. doi: 10.1016/0002-9394(77)90729-2.
Cataracts are an enormous medical, financial, and social burden. At least 300,000 to 400,000 new, visually disabling cataracts occur yearly in the United States, and 5 to 10 million worldwide. Complications of modern surgical techniques alone probably result in at least 7,000 irreversibly blind eyes annulally in the United States, and a potential 100,000 to 200,000 worldwide. These figures must be refined through well-standardized prevalence surveys and careful monitoring of indications and results of surgery. Senile cataracts probably result from many, possibly compound, obscure causes. Race, altitude, dietary habits, and deranged carbohydrate metabolism are some that have been suggested. There is little basis for the common belief that senile cataracts are more prevalent, or mature more rapidly, in diabetics. Carefully conducted case control and long-term studies are needed to assess the importance of each of these factors and to identify additional ones. The rapid increase of intraocular lens implantation raises serious questions of safety and efficacy. Implantation increases the risk of corneal and macular edema, iritis, and reoperation for lens dislocation and membrane formation, while complicating the treatment of retinal detachments and retinovascular disease. They require controlled clinical evaluation.
白内障是一个巨大的医学、经济和社会负担。在美国,每年至少有30万至40万例新的致盲性白内障出现,全球范围内则有500万至1000万例。仅现代手术技术的并发症,在美国每年可能就导致至少7000只眼睛不可逆地失明,在全球范围内可能达到10万至20万只。这些数字必须通过标准化的患病率调查以及对手术指征和结果的仔细监测来完善。老年性白内障可能由多种,甚至可能是复合的、不明的原因引起。种族、海拔、饮食习惯以及碳水化合物代谢紊乱等因素都曾被提及。普遍认为糖尿病患者中老年性白内障更为常见或成熟更快,这种观点几乎没有依据。需要进行精心设计的病例对照研究和长期研究,以评估每个因素的重要性,并确定其他因素。人工晶状体植入的迅速增加引发了严重的安全性和有效性问题。植入会增加角膜和黄斑水肿、虹膜炎的风险,以及因晶状体脱位和膜形成而再次手术的风险,同时会使视网膜脱离和视网膜血管疾病的治疗变得复杂。它们需要进行对照临床评估。