Haga H J, Brun J G, Berntzen H B, Cervera R, Khamashta M, Hughes G R
Department of Rheumatology, Haukeland Hospital, Bergen, Norway.
Lupus. 1993 Feb;2(1):47-50. doi: 10.1177/096120339300200108.
Calprotectin (L1) is a granulocyte and monocyte cytosolic protein released during activation of these cells. The plasma level of L1 has been shown to be a good marker of disease activity in rheumatoid arthritis. In this cross-sectional study of 100 patients with systemic lupus erythematosus (SLE), the serum level of L1 was found to be higher in patients than in matched controls (3661 micrograms/l versus 1051 micrograms/l; P < 0.001). The serum level of L1 was the only laboratory parameter with significant association to the disease activity index SLEDAI (r = 0.28; P < 0.01). Furthermore, the serum level of L1 was significantly higher in SLE patients with anti-DNA antibodies compared to patients without anti-DNA antibodies (4501 micrograms/l versus 3279 micrograms/l; P = 0.01). SLE patients with arthritis had higher serum levels of L1 than patients without arthritis (7652 micrograms/l versus 2811 micrograms/l; P < 0.01), indicating that the serum level of L1 also reflects arthritis activity in SLE.
钙卫蛋白（L1）是一种在这些细胞激活过程中释放的粒细胞和单核细胞胞质蛋白。L1的血浆水平已被证明是类风湿性关节炎疾病活动的良好标志物。在这项对100例系统性红斑狼疮（SLE）患者的横断面研究中，发现患者血清中L1水平高于匹配的对照组（3661微克/升对1051微克/升；P<0.001）。L1血清水平是与疾病活动指数SLEDAI有显著相关性的唯一实验室参数（r = 0.28；P<0.01）。此外，与无抗DNA抗体的SLE患者相比，有抗DNA抗体的SLE患者血清L1水平显著更高（4501微克/升对3279微克/升；P = 0.01）。有关节炎的SLE患者血清L1水平高于无关节炎的患者（7652微克/升对2811微克/升；P<0.01），表明L1血清水平也反映了SLE中的关节炎活动情况。
