Baker H F, Ridley R M, Wells G A
Division of Psychiatry, Clinical Research Centre, Harrow, Middlesex.
Vet Rec. 1993 Apr 17;132(16):403-6. doi: 10.1136/vr.132.16.403.
Two young male common marmosets (Callithrix jacchus) were injected intracerebrally and intraperitoneally with a crude brain homogenate prepared from a cow with bovine spongiform encephalopathy (BSE). Two other marmosets were similarly injected with brain homogenate from a sheep with natural scrapie. The two animals injected with scrapie material developed neurological signs 38 and 42 months after injection and the two animals injected with BSE material developed neurological signs after 46 and 47 months. Post mortem examination of the brains revealed spongiform encephalopathy especially in the basal nuclei and diencephalon of all the animals and, in addition, involvement of the cerebral cortex of the marmosets injected with scrapie material. The experiment extends the host range of experimental BSE to include a primate species.
给两只年轻的雄性普通狨猴（Callithrix jacchus）脑内和腹腔内注射了用患牛海绵状脑病（BSE）的奶牛制备的粗脑匀浆。另外两只狨猴同样被注射了患有自然痒病的绵羊的脑匀浆。注射痒病材料的两只动物在注射后38个月和42个月出现神经症状，注射BSE材料的两只动物在46个月和47个月后出现神经症状。对大脑进行尸检发现，所有动物均出现海绵状脑病，尤其是在基底核和间脑，此外，注射痒病材料的狨猴的大脑皮层也受到影响。该实验将实验性BSE的宿主范围扩大到包括一种灵长类动物。
