Hirschman S Z, Meyers B R, Miller A
Antimicrob Agents Chemother. 1977 Feb;11(2):369-71. doi: 10.1128/AAC.11.2.369.
A patient with Salmonella typhi bacteremia was sucessfully treated with cefamandole, a new cephalosporin derivative. Infection has not recurred during 6 months of follow-up observation. Minimum inhibitory concentrations and minimum bactericidal concentrations of cefamandole, cephalothin, ampicillin, and chloramphenicol were compared against 26 strains of S. typhi. All the strains were susceptible to cefamandole in vitro. Seven of the strains were resistant to chloramphenicol, and another seven were resistant to both chloramphenicol and ampicillin. Cefamandole appears to warrant further clinical trial for the treatment of typhoid fever.
一名伤寒沙门菌菌血症患者用新型头孢菌素衍生物头孢孟多成功治愈。在6个月的随访观察期内感染未复发。比较了头孢孟多、头孢噻吩、氨苄西林和氯霉素对26株伤寒沙门菌的最低抑菌浓度和最低杀菌浓度。所有菌株在体外对头孢孟多均敏感。7株菌株对氯霉素耐药，另有7株对氯霉素和氨苄西林均耐药。头孢孟多似乎值得进一步进行治疗伤寒热的临床试验。
