Levison M E, Santoro J, Bran J L, Ries K, Rubin W
J Infect Dis. 1977 Mar;135 Suppl:S49-53. doi: 10.1093/infdis/135.supplement.s49.
Clindamycin, rosamicin, josamycin, and metronidazole had similar inhibitory activity against 29 clinical isolates of Bacteroides fragilis, i.e., 100% of strains were inhibited by 0.8 microng of metronidazole or josamycin/ml and 100% by 1.6 microng of clindamycin or rosamicin/ml. Metronidazole was bactericidal against 97% of the isolates, and clindamycin or rosamicin (in concentrations of 1.6 microng/ml) was bactericidal against 80%. Erythromycin and josamicin were the least bactericidal agents in vitro. Thirty-two patients with pleuropulmonary and intraabdominal or pelvic infections caused by anaerobic bacteria were treated with clindamycin. Cure was achieved in 27 patients. In another group of 37 patients treated with parenteral clindamycin, diarrhea developed in 30% and was significantly more common in those patients with abdominal or pelvic infection. Only one patient developed pseudomembranous colitis. These observations suggest that clindamycin is an excellent and relatively safe antibiotic for treatment of infections caused by anaerobes when combined with surgery or with other antibiotics selected for activity against aerobic gram-negative bacilli.
克林霉素、罗沙米星、交沙霉素和甲硝唑对29株脆弱拟杆菌临床分离株具有相似的抑制活性，即每毫升含0.8微克甲硝唑或交沙霉素时，100%的菌株受到抑制，每毫升含1.6微克克林霉素或罗沙米星时，100%的菌株受到抑制。甲硝唑对97%的分离株有杀菌作用，克林霉素或罗沙米星（浓度为每毫升1.6微克）对80%的分离株有杀菌作用。红霉素和交沙霉素是体外杀菌作用最弱的药物。32例由厌氧菌引起的胸膜肺部、腹腔内或盆腔感染患者接受了克林霉素治疗。27例患者治愈。在另一组37例接受静脉注射克林霉素治疗的患者中，30%出现腹泻，在腹部或盆腔感染患者中更为常见。只有1例患者发生假膜性结肠炎。这些观察结果表明，克林霉素与手术或与其他针对需氧革兰氏阴性杆菌活性选择的抗生素联合使用时，是治疗厌氧菌感染的一种优良且相对安全的抗生素。
